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Completed

NCT Number: NCT01612403

Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen

There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements like zinc. Zinc in human seminal plasma was divided into three types of ligands which are high (HMW), intermediate (IMW), and low molecular weight ligands (LMW). The present study was conducted to study the effect of Zn supplementation on the quantitative and qualitative characteristics of semen along with Zinc Binding Protein levels in semen of patients with asthenozoospmia.

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Key information

Conditions

Asthenozoospermia Genital Diseases Genital Diseases, Male Infertility Infertility, Male Male Urogenital Diseases Urogenital Diseases

Age range

27 year–35 year

Sex eligibility

Male

Study type

Observational

Primary location

Babylon University, Hillah, Hilla, Iraq

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About this study

Elevation of ROS levels lead to an increase the oxidation of HMW-Zn binding proteins in seminal plasma of asthenozoospermic subjects. Zinc supplementation restores HMW-Zn% in seminal plasma of asthenozoospermic subjects to normal value. LMW-Zn% is elevated in seminal plasma of asthenozoospermic patients. It may be because increment the levels of semenogelin in seminal plasma of asthenozoospermic subjects. Zinc supplementation elevates LMW-Zn% in seminal plasma of asthenozoospermic subjects to more than normal value, this may be because of its enhancement of the synthesis of metallothioneins (Low molecular weight zinc binding protein).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The inclusion criteria were the presence of asthenozoospermia in the semen sample.

Exclusion criteria

  • the absence of endocrinopathy,
  • varicocele, and
  • female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Treatment and study plan

zinc sulfate

Dietary Supplement

every participant took two capsules of zinc sulfate per day for three months (each one 220mg)

Other names: infertility

Primary outcomes

  1. high molecular weight zinc binding protein

    Time frame: at the end of three months

    elevated levels of high molecular weight zinc binding protein to normal value

Secondary outcomes

  1. qualitative semen parameters

    Time frame: at the end of three months

    Volume of semen, progressive sperm motility percentage and total normal sperm count increased after zinc sulfate supplementation.

Sponsors and collaborators

Lead sponsor

mahmoud hussein hadwan

Other

Registry information

Acronym: supplement

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Jun 5, 2012
Registry last updated
Jun 6, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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