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NCT Number: NCT07294937

Study Protocol: 10-Year Follow-Up of Patients Screened for Cardiovascular Risk by the "All With Heart" Association - Development of a Morocco-Specific Risk Score

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and their prevalence is steadily increasing in Morocco. Between 2010 and 2012, the "All with heart" Association conducted a large-scale cardiovascular screening campaign in the Greater Casablanca region, involving more than 10,000 adults aged over 40 years. This 10-year follow-up study aims to evaluate long-term cardiovascular outcomes and to develop a Morocco-specific cardiovascular risk score. Follow-up data will be collected through phone calls, WhatsApp, or SMS with participants or their families to document cardiovascular deaths, myocardial infarctions, and strokes. Statistical analyses, including survival analysis and multivariate logistic regression, will be used to identify significant risk factors and to construct a predictive risk model tailored to the Moroccan population. The study received a favorable opinion from the Rabat Ethics Committee. Written informed consent will be obtained from all participants or their families prior to data collection. The findings are expected to enhance understanding of cardiovascular risk evolution in Morocco and to provide a validated, population-specific risk score to support prevention and patient management strategies.

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Key information

Conditions

Cardiovascular Diseases (CVD) Cardiovascular Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Moroccan Society of Cardiology, Casablanca, Morocco

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 40 years or older at the time of the initial screening (2010-2012).
  • Individuals who participated in the cardiovascular risk screening campaign conducted by the "All with heart" Association between 2010 and 2012 in the Greater Casablanca region.
  • Moroccan nationality.
  • Participants or family members who provide written informed consent for participation in the 10-year follow-up study.

Exclusion criteria

  • Individuals who refuse to participate in the follow-up study.
  • Participants who have moved and cannot be reached by phone, WhatsApp, or SMS.
  • Participants who died from non-cardiovascular causes.
  • Non-Moroccan participants.

Treatment and study plan

Primary outcomes

  1. Incidence of Major Cardiovascular Events (MACE)

    Time frame: 10 years after initial screening (2010-2012)

    Occurrence of major cardiovascular events (myocardial infarction, stroke, or cardiovascular death) among participants screened for cardiovascular risk between 2010 and 2012 by the "All with heart" Association. Events will be identified during the 10-year follow-up period through participant or family contact (phone, WhatsApp, or SMS) and verified through available medical records when possible.

  2. Development and Validation of a Morocco-Specific Cardiovascular Risk Score

    Time frame: Baseline (2010-2012) and 10-year follow-up (2022)

    Development and internal validation of the Morocco-Specific Cardiovascular Risk Score, a composite risk prediction score estimating the 10-year probability of major cardiovascular events including myocardial infarction, stroke, or cardiovascular death. The score will be derived from baseline cardiovascular risk factors collected during the initial screening and weighted using multivariable regression models based on outcomes observed during the 10-year follow-up. The score will be expressed on a scale ranging from 0 to 100, where higher scores indicate a higher cardiovascular risk and therefore a worse outcome. Model performance will be assessed using discrimination and calibration measures, including the area under the receiver operating characteristic curve and calibration analyses.

Secondary outcomes

  1. Incidence of Minor Cardiovascular Events

    Time frame: 10 years after initial screening (2010-2012)

    Occurrence of minor cardiovascular events, including stable or unstable angina, among participants screened between 2010 and 2012. Events will be collected through participant or family interviews and verified with medical records when available.

Other outcomes

  1. Number of Hospitalizations Related to Cardiovascular Diseases

    Time frame: 10 years after initial screening (2010-2012)

    Total number of hospitalizations due to cardiovascular causes (acute coronary syndrome, heart failure, arrhythmia, or cardiac surgery) during the 10-year follow-up period.

  2. Change in Cardiovascular Risk Factors Over Time

    Time frame: 10 years after initial screening (2010-2012)

    Change in major cardiovascular risk factors (body mass index, blood pressure, total cholesterol, triglycerides, HDL, blood glucose, smoking status, and physical activity) between the initial screening and the 10-year follow-up.

  3. Quality of Life Assessment

    Time frame: 10 years after initial screening (2010-2012)

    Evaluation of participants' quality of life using a standardized questionnaire (EQ-5D). The assessment will explore mobility, self-care, usual activities, pain/discomfort, and anxiety/depression dimensions.

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed ALAMI

CONTACT

Najat MOUINE, Professor of Cardiology

CONTACT

[email protected]

+212661202733

Sponsors and collaborators

Lead sponsor

Moroccan Society of Cardiology

Other

Collaborators

  • F&C Clinical Trials

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 19, 2025
Registry last updated
Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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