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Completed

NCT Number: NCT00847743

Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation

Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation.

Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives.

We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.

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Key information

Conditions

Oxidative Stress Antioxidant Capacity Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

55 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kronos Longevity Research Institute

Phoenix, Arizona, 85016, United States

About this study

Objectives

The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • men and women, ages 55-80y, in good health, with >8 years of education
  • non-smoker
  • able to give informed consent

Exclusion criteria

  • use of anti-oxidant supplements, in excess of a standard multi-vitamins
  • current hormone replacement therapy
  • any history of significant chronic disease
  • uncontrolled hypertension
  • body mass index (BMI) > 30 kg/m2
  • high physical activity level, as determined by questions on the screening questionnaire
  • use of anti-inflammatory medication

Treatment and study plan

Tart cherry juice

Dietary Supplement

8 fl.oz. twice per day

Other names: CherryPharm

Primary outcomes

  1. plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge.

Secondary outcomes

  1. Urinary markers of oxidative damage.

Sponsors and collaborators

Lead sponsor

Kronos Longevity Research Institute

Other

Collaborators

  • Vanderbilt University

Registry information

Official study title

Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Feb 19, 2009
Registry last updated
Feb 19, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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