Study on the Measurement of Retinal Blood Flow in Children

In order to provide reference for clinical application, the normal values of retinal blood flow parameters in Chinese healthy children were measured by oct-angiography. Meanwhile, the repeatability and consistency of retinal blood flow parameters measured by oct-angiography in children were further analyzed, and the correlation of retinal blood flow parameters with eye axis, choroidal thickness, age and diopter was analyzed, so as to provide basis for clinical diagnosis of children's ophthalmopathy. Objective to study the effect of short-term optical defocusing on retinal blood flow parameters, and analyze the correlation between the changes of posterior segment parameters before and after short-term optical defocusing, so as to provide the basis for the possible compensation mechanism of posterior segment optical defocusing, and further understand the possible physiological mechanism of myopia.

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Key information

Conditions

Myopia Eye Diseases Refractive Errors

Age range

6 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The affiliated Eye Hospital of Wenzhou Medical College

Wenzhou, Zhejiang, 325027, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The subjects should be 6-18 years old, with parents' consent and be able to abide by the experimental rules;
uncorrected visual acuity or spectacle corrected visual acuity ≥ 1.0, and each eye can fix the target;
equivalent spherical lens range + 0.50D ~ - 6.00D, binocular spherical lens anisometropia ≤ 1D, anisometropia ≤ 1.5D;
frame glasses can be worn for patients with ametropia, and hard contact lenses can not be worn for at least 4 weeks, and anisometropia can not be worn for 2 weeks
intraocular pressure in the normal range (9mmhg-21mmhg)

Exclusion criteria

Patients with history of ocular trauma and surgery;
patients with ocular organic lesions or systemic diseases;
patients with dry eye;
patients in the treatment period using drugs (such as atropine eye drops);
patients with poor cooperation or unqualified image quality

Treatment and study plan

Primary outcomes

Blood flow density measurement

Time frame: 2017.05.01-2019.11.11

The vascular density was defined as the percentage of the area occupied by the vascular cavity after secondary reconstruction. The percentage of vascular lumen in macular area is automatically displayed based on the early treatment of diabetic retinopathy study (ETDRS) partition (i.e. macular area, paramacular area, temporal area, last time area, nasal area and inferior area), and the other partition method is based on the "Nine Palace" partition (i.e. central macular area, supratemporal area, superior area, Supranasal area, nasal area, infranasal area, inferior area, infratemporal area and temporal area)

Secondary outcomes

Macular avascular area measurement

Time frame: 2017.05.01-2019.11.11

The new non vascular area measurement option was used to automatically measure the FAZ area. The boundary of avascular zone is detected and defined by system software and quantified automatically. The reference range of shallow retinal foveal avascular zone,It was defined as within 60 LM from the inner limiting membrane. In the images of shallow and deep capillary layers, the foveal avascular zone is measured automatically by clicking the center of foveal avascular zone.

Sponsors and collaborators

Lead sponsor

Wenzhou Medical University

Other

Registry information

Official study title

Study on the Measurement of Retinal Blood Flow in Children Based on Oct Angiography and the Effect of Optical Defocus Application

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2019
First posted: Dec 30, 2020
Registry last updated: Dec 30, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed