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NCT Number: NCT07704255

Study on the Effect of Fecal Microbiota Transplantation on Eradication of Refractory Helicobacter Pylori Infection

To determine whether regulating the gut microbiota can contribute to the eradication of refractory H. pylori infection.

Recruiting

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Sichuan Provincial People's Hospital

Chengdu, Sichuan, 601172, China

Location status: Recruiting

Location contact

Caiping Gao, Doctor

CONTACT

[email protected]

17708130286

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1. Ages 18-70
  • 2. Hp infection treatment failed ≥4 times with guidelines-recommended therapies
  • 3. Patients with early gastric cancer, peptic ulcer, gastric MALT lymphoma, atrophic gastritis and other diseases requiring the eradication of Hp.

Exclusion criteria

  • 1. Antibiotics and bismuth were taken within 4 weeks before this treatment; Or had taken PPI, H2 receptor antagonist, P-CAB within 2 weeks prior to treatment;
  • 2. Pregnant or lactating women;
  • 3. Those who are allergic to the investigational drugs used in this test or have contraindications;
  • 4. Participated in other drug trials within 3 months before the treatment of this trial;
  • 5. There are other serious diseases that affect the evaluation of this study at the same time, or they cannot correctly express their own complaints and cannot cooperate;
  • 6. Subjects with dysphagia;
  • 7. Patients with malignant tumors, serious concomitant diseases, severe ulcer bleeding or perforation;
  • 8. Patients judged by the investigator to be unsuitable for clinical trials.
  • 9. Those who do not want to sign the informed consent for the study.

Treatment and study plan

transanal fecal bacteria transplant

Biological

Received transanal fecal bacteria transplant

Primary outcomes

  1. Whether Hp is successfully eradicated

    Time frame: 2years

    The successful eradication of Hp was determined by 13C urea breath test, immunohistochemical staining of Hp and Hp culture.test, immunohistochemical staining of gastric mucosa and Hp culture

Study contacts

Contact information is provided by the study sponsor or research team.

Gao Caiping, Doctor

CONTACT

[email protected]

17708130286

Xia Yuehan, Master

CONTACT

[email protected]

13438917607

Sponsors and collaborators

Lead sponsor

Sichuan Provincial People's Hospital

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 15, 2026
Registry last updated
Jul 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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