Skip to main content
OpenTrials
Completed

NCT Number: NCT03976739

Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.

To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Bile Reflux Gastritis Bile Reflux Biliary Tract Diseases Digestive System Diseases Digestive System Neoplasms Duodenogastric Reflux Gastric Cancer Gastrointestinal Diseases Gastrointestinal Neoplasms Helicobacter Pylori Infection Intestinal Metaplasia Neoplasms Neoplasms by Site Precancerous Lesions Stomach Diseases Stomach Neoplasms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Xijing Hosipital of Digestive Disease

Xi'an, Shaanxi, 710032, China

About this study

This study was a multicenter cross-sectional study. Patients were consecutively enrolled and divided into gastric cancer group, gastric precancerous lesions group, and chronic gastritis group, according to histopathological results. The bile reflux detection rate and Helicobacter pylori infection status were recorded for each group.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 to 75 years old, gender is not limited;
  • patients with upper abdominal pain, abdominal distension, belching, anorexia, early satiety, hiccup, acid reflux, upper abdomen burning sensation and other upper gastrointestinal symptoms;
  • Voluntary acceptance of Hp testing;
  • Voluntary acceptance of the endoscopy and pathological biopsy.

Exclusion criteria

  • had undergone upper gastrointestinal surgery;
  • Previous diagnosis of esophageal cancer;
  • Previous diagnosis of gastric cancer;
  • Previous diagnosis of MALT lymphoma;
  • pregnant and lactating women;
  • Those with mental disorders;
  • Refusal to sign the informed consent form.

Treatment and study plan

Primary outcomes

  1. corelation between the bile reflux and gastric mucosa diseases

    Time frame: up to 6 months

    we evaluate the corelation between the bile reflux and gastric mucosa diseases according to the histopathological results and the scales the patients finished

Secondary outcomes

  1. the risk factors of primary bile reflux gastritis

    Time frame: up to 6 months

    we evaluate the the risk factors of primary bile reflux gastritis according to the scales and endoscopical results

Sponsors and collaborators

Lead sponsor

Xijing Hospital of Digestive Diseases

Other

Registry information

Official study title

Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Multiple Center, Cross-sectional Study.

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Jun 6, 2019
Registry last updated
Aug 12, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.