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Completed

NCT Number: NCT03225027

Study on Communication Comprehension in the Schizophrenic Spectrum

The purpose of the present study is to evaluate the effect of emotional prosody on the perception of emotional discourse in the schizophrenic spectrum. The investigators hypothesize that participant may use emotional prosody as an emotional cue to understand the emotional content of discourse.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

HDJ François Villon

Cergy-Pontoise, 95303, France

About this study

The integration of ortholinguistic and paralinguistic functions in language, particularly of the emotional prosody, is necessary to interact adaptively with others. People in the schizophrenic spectrum have social difficulties. Is emotional prosody comprehension altered in these people? According to Edwards et al. (2002), there is methodological issues concerning the tasks used to answer this question. Investigators built an emotional judgment task more adapted to study the perception of emotional prosody in the schizophrenic spectrum than the classical paradigm designed to evaluate participants with cerebral injury. The investigators have elaborated a material that consists of 140 short sentences (7±2 words) with a simple syntactic structure. The verbal content expressed positive, neutral or negative emotions. These sentences were announced by four professional actors (two female) with an emotional prosody content congruent or inconsistent with the verbal content. Participants will have to evaluate the emotional intensity of the recordings on a five points Likert scale, from strongly negative to strongly positive. Psychotic experiences of all participants will be evaluated too.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Having a diagnosis of schizophrenia and being in a stable phase of the disease
  • Having between 18 to 60 years old
  • Speak french or using french at school
  • Accepting not to use psychoactive substances during the preceding 48h
  • Being affiliated to the French social security
  • Providing their written informed consent

Non-inclusion Criteria:

  • Having not audio deficits, nor visual uncorrected deficits
  • Having not suffering from depressive symptoms during the last 6 months

Exclusion criteria

  • Having no neurological, nor psychiatric disease except schizophrenia for the patients groups.

Treatment and study plan

Emotional judgment task

Behavioral

Participants had to indicate on a computer the emotional intensity of audio recordings.

Post-experimental questionnaire

Behavioral

Participants will be invited to give us the cognitive strategy used to resolve the emotional judgment task.

Recognition task

Behavioral

Participants will be invited to indicate which recordings they had heard during the emotional judgment task to verify that they have paid attention to the emotional task.

Detection task

Behavioral

Participants indicate every time they heard a given sound in order to verify their audition level.

CAPE-42

Other

This questionnaire allows evaluating the nature of psychotic experiences.

Trait Emotional Intelligence Questionnaire

Diagnostic Test

To evaluate their emotional intelligence.

Other names: TEIQUE

Positive And Negative Syndrome Scale

Diagnostic Test

Evaluating the clinical status of patients with schizophrenia.

Other names: PANSS

Mini International Neuropsychiatric Interview

Other

Evaluating the exclusion criteria in healthy participants.

Other names: MINI

Primary outcomes

  1. Behavioural measures (response rate and time)

    Time frame: During the experiment

    Participants will have to judge the emotional intensity of audio recordings. In this task, the participant is asked to judge the emotional intensity of audio recordings of men and women (2 actors + 2 actresses): he / she must press a button as quickly as possible to indicate whether the Audio recordings presented via small speakers are very negative, negative, non-emotional, positive or very positive (5 possible choices).

    The response time variable may be added as a co-variable in order to avoid perceptive-motor disorders (medication-related and / or general motor slowdown) that may influence the results of time-of- answers.

Secondary outcomes

  1. Symptomatic impact

    Time frame: During the experiment

    Evaluate the nature of the psychotic experiments (CAPE-42 test).

  2. Evaluate the cognitive functioning

    Time frame: During the experiment

    Neuropsychological tests will allow evaluating the cognitive profile of the participants that can impact their behaviour during the experiment.

Sponsors and collaborators

Lead sponsor

Hôpital NOVO

Other

Registry information

Acronym: SKYPROVERB

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Jul 21, 2017
Registry last updated
Jul 29, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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