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Completed

NCT Number: NCT02248987

Study on Abnormal Dopamine Synthesis and Connectivity According to the Antipsychotic Treatment Response in Schizophrenia

The purpose of this study is to evaluate abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia.

Completed

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

20 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of schizophrenia
  • clinically stable state

Exclusion criteria

  • history of previous head injury, epileptic disorder, other medical comorbidity
  • substance abuse/dependence

Treatment and study plan

patients treated with antipsychotics

Other

Primary outcomes

  1. Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging.

    Time frame: within 2 weeks from enrollment

Secondary outcomes

  1. resting state functional magnetic resonance imaging

    Time frame: within 2 weeks from enrollment

  2. diffusion tensor imaging

    Time frame: within 2 weeks from enrollment

  3. clinical measure including Positive and Negative Syndrome Scale

    Time frame: within 2 weeks from enrollment

  4. neurocognitive function test

    Time frame: within 2 weeks from enrollment

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Sep 25, 2014
Registry last updated
Apr 8, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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