Study of Vitamin A and Carbomer in Comforting the Ocular Surface Irritations of Glaucoma Patients

Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to search for new drugs for therapy. The investigators hypothesized that the artificial tears containing vitamin A or carbomer may be a great substitute. Both of the two drugs were in common use and had already been tested in animals.

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Key information

Conditions

Primary Open-Angle Glaucoma Eye Diseases Glaucoma Glaucoma, Open-Angle Ocular Hypertension

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

diagnosed primary open-angle glaucoma or normal tension glaucoma patients with prostaglandin analogs treatment for more than one year.

Exclusion criteria

any systemic diseases which may cause ocular damage;
previous ocular trauma or surgery;
contact lens wear history in previous 6 months;
application of any artificial tears 3 months ago;
allergic to any of the drugs we used during examination.

Treatment and study plan

Vitamin A

Drug

use one drop in the eye

Other names: vitamin A palmitate eye gel

carbomer eye gel

Drug

use one drop in the eye

Other names: Carbomer Eye Drops

Primary outcomes

change of the density of conjunctival goblet cells

Time frame: change from Baseline in goblet cell density at 6 months

Secondary outcomes

tear film parameters changes in patients

Time frame: change from baseline in TBUT and Schirmer test at 6 months
changes of ocular irritation in patients

Time frame: change from baseline in OSDI scores at 6 months

Sponsors and collaborators

Lead sponsor

Xiaodong Zhou

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2013
Study completion: 2013
First posted: Mar 4, 2014
Registry last updated: Mar 5, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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