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Completed

NCT Number: NCT01185769

Study of Tocotrienol Absorption and Distribution Under Different Fat Status

Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols

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Key information

Conditions

Absorption

Age range

22 year–25 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Malaysian Palm Oil Board

Bangi, Selangor, 43000, Malaysia

About this study

There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male aged 22-25
  • body mass index 18.5 < X < 30 kg/m2
  • plasma cholesterol < 5.2 mmol/L,
  • TAG < 1.7 mmol/L

Exclusion criteria

  • history of cardiovascular disease
  • diabetic
  • body mass index < 18.5 or > 30 kg/m2
  • plasma cholesterol > 5.2 mmol/L,
  • TAG > 1.7 mmol/L
  • hypertension
  • currently taking Vitamin E supplement
  • current use of medication
  • smoking.

Treatment and study plan

Tocotrienol

Dietary Supplement

500 mg of tocotrienol will be administered after consumption of high fat diet

Primary outcomes

  1. Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol

    Time frame: 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 24 hours after tocotrienol administration and in take of designated meal

Sponsors and collaborators

Lead sponsor

Malaysia Palm Oil Board

Other Gov

Collaborators

  • University of Malaya

Registry information

Official study title

Mechanism of Absorption and Distribution of Tocotrienols Under Different Food Status

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Aug 20, 2010
Registry last updated
Aug 20, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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