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OpenTrials
Completed

NCT Number: NCT01414595

Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.

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Key information

Conditions

Lung Cancer Adenocarcinoma Adenocarcinoma of Lung Bronchial Neoplasms Carcinoma Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles, California, United States

Loading trial locations.

About this study

OBJECTIVES:

  • To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens.
  • To identify and characterize structural variations in the genomes of NSCLC specimens.
  • To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation.

OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • Patient must have been registered to CALGB 140202.
  • Tumor histology should be either primary adenocarcinoma or squamous cell carcinoma of the lung.
  • Patients are eligible for this study if their samples from CALGB 140202 are available.
  • All living patients must sign the CALGB 151107 consent form to be eligible for this trial.

Treatment and study plan

DNA analysis

Genetic

DNA methylation analysis

Genetic

RNA analysis

Genetic

gene expression analysis

Genetic

polymorphism analysis

Genetic

laboratory biomarker analysis

Other

medical chart review

Other

Primary outcomes

  1. Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung

    Time frame: up to 5 years

  2. Identification and characterization of structural variations in the genomes of NSCLC

    Time frame: up to 5 years

  3. Identification and characterization of other genomic alterations including, but not limited to, gene expression profiling and methylation

    Time frame: up to 5 years

Sponsors and collaborators

Lead sponsor

Alliance for Clinical Trials in Oncology

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)

Important dates

Study start
2012
Primary completion
2017
First posted
Aug 11, 2011
Registry last updated
Jun 27, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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