Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents

This study is designed to determine whether there is a relationship between the way insulin and blood vessels work. The difference in the interaction between Caucasian and African American adolescents will also be examined. This may play a role in the differing rates of heart disease and diabetes between the two groups.

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Key information

Conditions

Diabetes Mellitus, Type 2 Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Heart Disease Heart Diseases Hyperinsulinism Hypertension Insulin Resistance Metabolic Diseases Nervous System Diseases Nutritional and Metabolic Diseases Stroke Vascular Diseases

Age range

8 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ohio State University

Columbus, Ohio, 43210, United States

About this study

Purpose: The purpose of the research is to learn more about how the lining of arteries in the body (called the endothelium) and insulin work in adolescents. Abnormalities in how the blood vessels and insulin work in adolescents may cause high blood pressure, type 2 diabetes, stroke and heart disease.

Healthy adolescents between 8 and 18 years of age are being studied in the Ohio State University General Clinical Research Center. Two visits will be necessary. One will be a screening visit to determine the child's stage of puberty and obtain a medical history. The second will be the study visit. During the latter, blood vessel function will be determined by studying the change in forearm blood flow before and after blood flow to the forearm is stopped. Insulin sensitivity will be determined using glucose water given into a vein.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Caucasian or African American adolescent
Between 8 and 18 years of age

Exclusion criteria

Pregnancy
Chronic Disease
Acute Disease
Medication Requirement

Sponsors and collaborators

Lead sponsor

Ohio State University

Other

Collaborators

Nationwide Children's Hospital

Registry information

Official study title

Relationship of Endothelial Function to Insulin Sensitivity in African American and Caucasian Adolescents

Important dates

Study start: 2003
Primary completion: 2006
Study completion: 2006
First posted: Sep 11, 2006
Registry last updated: Jun 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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