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Completed

NCT Number: NCT05095155

Study of the Prognostic Role of Gene Polymorphism in the Development of B-cell Leukemias and Lymphomas in Children of Kazakh Nationality

To search for a genetic marker of B-cell leukemias and lymphomas in children of Kazakh nationality, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with B-cell leukemias and lymphomas in children of Kazakh nationality and normal control will be performed.

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Key information

Conditions

B Cell Leukemia Hematologic Diseases Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Leukemia Leukemia, B-Cell Leukemia, Lymphoid Lymphatic Diseases Lymphoma Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type

Age range

0 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Scientific Center of Pediatrics and Pediatric Surgery

Almaty, Kazakhstan

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ethnicity - Kazakhs in at least three generations
  • active disease or a history of B-line ALL or B-NHL, established on the basis of morphological, cytochemical, immunophenotypic or immunohistochemical research methods with confirmation of the fact of the disease in medical documentation
  • Signed voluntary informed consent of the legal representative to participate in the project

Exclusion criteria

  • Children suffering from other types of malignant neoplasms
  • Children with B-linear leukemia and lymphomas with concomitant specified genetic and chromosomal diseases
  • Children of non-Kazakh nationality
  • Absence of signed informed consent or informed refusal of the legal representative to participate in the study before starting therapy

Treatment and study plan

SNP analysis of the DNA

Genetic

SNP analysis of the DNA obtained from peripheral blood sample

Other names: SNP analysis of the DNA obtained from peripheral blood sample

Primary outcomes

  1. Associated with B-cell lymphoma and B-cell acute lymphoblastic leukemia

    Time frame: 1 year

    Genotype frequency of SNP in the study genes of participants and control participants.

Sponsors and collaborators

Lead sponsor

Asfendiyarov Kazakh National Medical University

Other

Registry information

Official study title

Preventive and Personalized Medicine (2021-2023)

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Oct 27, 2021
Registry last updated
Mar 14, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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