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NCT Number: NCT03626233

Study of the Physiology of Pre-eclampsia and Vascular IUGR With Constitution of a Biological Collection

Preeclampsia and intrauterine growth retardation (IUGR) are serious and frequent pathologies, specific to pregnancy. They represent 70 000 new cases a year, or 9% of pregnancies and cause 50,000 premature births per year in France. The consequences in terms of morbidity and perinatal morbidity and the medical and economic costs make it an issue public health. Pre-eclampsia associates maternal hypertension with dysfunction kidney. There is no cure for pre-eclampsia or IUGR vascular during pregnancy. These pathologies invariably evolve towards a maternal and / or fetal aggravation sometimes very fast. Primary prevention and secondary education and screening for these pathologies are still insufficient. A better understanding of the pathophysiology of these placental vascular pathologies is necessary for the development of supported medical, obstetric and pediatric that will improve the state of health maternal and neonatal

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Key information

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

CHi Creteil

Créteil, 94000, France

Location status: Recruiting

Location contact

Diane REDEL

CONTACT

[email protected]

145175530 ext. 0033

Edouard LECARPENTIER, MD PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • pregnant women
  • With or without vascular pathology

Exclusion criteria

  • refusal to participate
  • multiple pregnancy
  • major fetal malformation diagnosed during pregnancy follow-up

Treatment and study plan

collect of placenta, blood and urinary samples at delivery

Other

collect of placenta, blood and urinary samples at delivery

Primary outcomes

  1. genomic analysis on placenta

    Time frame: day of delivery

    by chromatin immunoprecipitation-sequencing (ChIP-seq)

Secondary outcomes

  1. genomic analysis on blood

    Time frame: day of delivery

    by ChIP-seq

  2. genomic analysis on placenta

    Time frame: day of delivery

    by immunohistochemistry an polymerase chain-reaction

  3. VEGF blood level

    Time frame: day of delivery

  4. PLGF blood level

    Time frame: day of delivery

  5. sFlt1 blood level

    Time frame: day of delivery

  6. sKDR blood level

    Time frame: day of delivery

Study contacts

Contact information is provided by the study sponsor or research team.

Diane REDEL

CONTACT

[email protected]

145175530 ext. 0033

camille Jung

CONTACT

[email protected]

157022268 ext. 0033

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Intercommunal Creteil

Other

Registry information

Official study title

Study of the Physiology of Pre-eclampsia and Vascular Intrauterine Growth Restriction With Constitution of a Biological Collection

Acronym: CPVP

Important dates

Study start
2018
Primary completion
2028
Study completion
2028
First posted
Aug 10, 2018
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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