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OpenTrials
Completed

NCT Number: NCT02236832

Study of the Neural Basis of Analogical Reasoning

Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

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Key information

Conditions

Frontotemporal Dementia Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Cranial Nerve Diseases Dementia Eye Diseases Frontotemporal Lobar Degeneration Healthy Subjects Mental Disorders Metabolic Diseases Movement Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Nutritional and Metabolic Diseases Ocular Motility Disorders Ophthalmoplegia Paralysis Pathological Conditions, Signs and Symptoms Progressive Supranuclear Palsy Proteostasis Deficiencies Signs and Symptoms Supranuclear Palsy, Progressive TDP-43 Proteinopathies Tauopathies

Age range

20 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ICM (Institut du cerveau et de la Moelle épinière)

Paris, 75013, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy subjects:

  • subject affiliated to national health insurance
  • informed consent signed
  • normal neurological examination
  • subject aged at least 20

Patients:

  • FTD or PSP diagnostic criteria filled
  • patient affiliated to national health insurance
  • informed consent signed

Exclusion criteria

  • Severe psychiatric symptomatology and psychotropic drug use
  • unability to understand or perform the cognitive tasks.

Treatment and study plan

Transcranial Magnetic Stimulation

Device

MRI imaging

Other

EEG recording

Other

Neuropsychological examination

Behavioral

Primary outcomes

  1. Performance in the implicat task

    Time frame: day of inclusion (one day)

    Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60).

    Participants will come only once during one day ot the research centre.

  2. Performance in the Similitude task

    Time frame: from inclusion to 4 months after inclusion

    Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40).

    Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.

Secondary outcomes

  1. recording of EEG

    Time frame: day of inclusion (one day)

    EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials.

    Participants will come only once during one day a the research centre.

  2. Analysis of MRI

    Time frame: day of inclusion (one day)

    T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls.

    Participants will come only once during one day at the research centre

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Collaborators

  • Fondation pour la Recherche Médicale

Registry information

Official study title

Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.

Acronym: ANALOG

Important dates

Study start
2015
Primary completion
2021
Study completion
2021
First posted
Sep 11, 2014
Registry last updated
Sep 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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