Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years

Rheumatoid arthritis (RA) is the most frequent form of chronic inflammatory rheumatism in adults. The erosive damage influences the functional prognosis in patients with RA. At present, there are no sufficiently sensitive and specific predictive markers of erosive damage.

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Key information

Conditions

Arthritis, Rheumatoid Arthritis Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Amiens

Amiens, 80054, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients consulting in the Department of Rheumatology at Amiens University Hospital
Age ≥ 18
RA meeting the 2010 ACR/EULAR criteria
Less than 2 years of RA progression
Effusion in at least 1 joint

Exclusion criteria

Inability to give informed consent
Ongoing pregnancy
Previous treatment with an anti-osteoporosis medication
Intra-articular corticoid or hyaluronic acid injection in the previous 6 months
Coagulation disorders preventing arthrocentesis
Incarceration or legal guardianship

Treatment and study plan

Blood

Biological

measurement of CaSR expression levels on synovial fluid monocytes

Primary outcomes

CaSR expression rate level on synovial monocytes

Time frame: 1 year

measured by flow cytometry

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: CASPER

Important dates

Study start: 2013
Primary completion: 2015
Study completion: 2015
First posted: Sep 9, 2016
Registry last updated: Sep 9, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed