Study of the Impact of the Regular Consumption of Polyphenol-rich Grape Juice on the Biological Parameters of Oxidative Stress and on Endothelial Function in Healthy Subjects

Inclusion criteria

• Subjects aged from 18 to 50 years
• Men and women
• With national health insurance cover
• With a Body Mass Index between 18.5 and 27.9
• Who have given their written informed consent to take part in the study.

Exclusion criteria

• Subjects unable to understand the nature and aims of the study and/or those who have difficulty communicating with the investigator.
• Adults under ward of court.
• Those in custody following a decision of the court or the administration.
• Subjects with a risk of a major change in their diet during the trial.
• Those who drink more than 5 cups of tea or coffee a day.
• Those who consumed more than 25 grammes of alcohol a day, every day of the year preceding the inclusion visit.
• Those who present a history of or current use of psycho-active substances (drugs such as cocain, morphine, heroin...).
• Subjects currently in a period of exclusion relative to another research protocol or for whom the annual cummulation of payments for participation in biomedical research has reached the annual ceiling.
• Presence of any treated chronic disease, and any acute disease within the 4 weeks preceding the inclusion and randomisation visit.
• Persons with diabetes treated with insulin or oral antidiabetics.
• Subjects on lipid-lowering therapy and/or on antioxidants (such as vitamin E, vitamin C, selenium, ß-carotene, Zinc) in the month preceding inclusion.
• Subjects taking multivitamin supplements in the month preceding inclusion.
• Pregnant or breast-feeding women