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NCT Number: NCT02549378

Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia

The microcirculatory alterations is common in circulatory failure, especially during sepsis. The severity of these changes and their sustainability are responsible of multi organ failure and ultimately death. The optimization of microcirculatory flow could be a central objective of the management of patients hospitalized in intensive care.

Microcirculation includes all blood vessels of a diameter smaller than 100 micrometer. It represents the largest heat exchange surface of the body and is involved in tissue oxygenation. Microcirculatory flow is conditioned by the macrocirculation (heart rate and blood pressure) and the state of the microcirculation (thrombosis, vasoconstriction ...). The role of the CO2 in regulating microcirculatory flow is little studied. A recent work of our team and the oldest work in the literature lead to believe that CO2 has a specific role in modulating microcirculatory flow. No study to date precisely studied the impact of changes in the microcirculatory flow carbonemia .

The hypocapnia test is carried out in a standardized manner by inhalation of a mixture enriched in CO2 7% allows a significant increase in carbonemia. Hypocapnia will in turn obtained by a calibrated voluntary hyperventilation test.

Direct visualization of microcirculation by confocal microscopy is now considered the gold standard for exploring the microcirculation.

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Key information

Conditions

Microcirculation Blood Circulation Hypocapnia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

CHU Saint-Etienne

Saint-Etienne, 42055, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients from achieving hypercapnia test the CHU of Saint-Etienne
  • non smoking
  • non diabetic
  • affiliated with or entitled to a social security system
  • Written consent

Exclusion criteria

  • subjects not performing the test hypercapnia in full
  • patients with dermatological pathology at the study area
  • patient with Raynaud's syndrome
  • Patients with known bleeding disorders
  • refusal to consent

Treatment and study plan

confocal microscopy

Device

microvessel diameter measured by confocal microscopy

Primary outcomes

  1. microcirculatory flow (cells / min) measured by confocal microscopy

    Time frame: Day1

    microcirculatory flow (cells / min) measured by confocal microscopy in hypocapnic patients

Secondary outcomes

  1. microvessel diameter (micrometer) measured by confocal microscopy

    Time frame: Day1

    microvessel diameter (micrometer) measured by confocal microscopy in hypocapnic patients

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Official study title

Study of the Impact of Changes in Carbonemia on Microcirculation in Patients - A Monocentric Study

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Sep 15, 2015
Registry last updated
Sep 15, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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