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Completed

NCT Number: NCT02217189

Study of the Effect of Oral Zinc Supplementation on Superoxide Radical Scavengers

Although several studies have considered the relationship between infertility and semen super oxide radical scavengers levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on superoxide radical scavengers activity which are important in fertility of the individual has been reported.

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Key information

Conditions

Asthenozoospermia Genital Diseases Genital Diseases, Male Infertility Infertility, Male Male Urogenital Diseases Urogenital Diseases

Age range

26 year–36 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 2

Primary location

Babylon University

Hillah, Babylon, 51002, Iraq

About this study

The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with superoxide radical scavengers activity in the seminal plasma of asthenospermic patients.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • the presence of asthenozoospermia in the semen sample.

Exclusion criteria

  • the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Treatment and study plan

zinc sulfate

Dietary Supplement

The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Primary outcomes

  1. Oxido-sensitive index level in spermatozoa and seminal plasma.

    Time frame: up to three months.

Secondary outcomes

  1. Volume of semen.

    Time frame: up to three months.

  2. Xanthine oxidase activity in spermatozoa and seminal plasma.

    Time frame: up to three months.

  3. Catalase like activity in spermatozoa and seminal plasma.

    Time frame: up to three months.

  4. Superoxide dismutase activity in spermatozoa and seminal plasma.

    Time frame: up to three months.

  5. Progressive sperm motility percentage.

    Time frame: up to three months

  6. Total normal sperm count.

    Time frame: up to three months.

Sponsors and collaborators

Lead sponsor

Babylon University

Other

Collaborators

  • Ministry of Health, Iraq

Registry information

Official study title

Study of the Effect of Oral Zinc Supplementation on Superoxide Radical Scavengers in Spermatozoa of Patients With Asthenospermia

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Aug 15, 2014
Registry last updated
Feb 3, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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