Study of the Diet in Patients With the Diagnostic of Acute Pancreatitis

This is prospective, randomized, controlled, multicentre trial. Patients with mild and moderate acute pancreatitis (AP) will be randomly in two groups: group A: with early oral refeeding (EOR) with low fat solid diet (LFSD), started from the first day of admission in the hospital, and group B: with Nil Per Oral (NPO), until the symptoms, signs, inflammatory parameters of AP have resolved.

The primary and several secondary endpoints will be obtained and EORF with LFSD will improve the following measures of outcome:

• Length of hospital admission (the primary endpoint)
• Serum amylase, lipase, electrolytes, calcium, urea, creatinine, liver function tests, C-reactive protein (biomarker of inflammation), nutritional parameters (albumin, prealbumin, cholesterol, triglycerides) and full blood count - routine blood tests performed daily until normalization of serum lipase or until discharge.
• Weight, at hospital admission and discharge, and at day 30 post-discharge clinic follow-up.
• Systemic complications including hemodynamic instability, renal failure, intensive care admission, surgery, radiological and endoscopic procedures.
• Pain and Analgesic requirement.
• Local complications including pancreatic necrosis, abscess, pseudocyst.

Inclusion criteria

• 1) Diagnosed of AP by at least two of these three criteria: compatible abdominal pain, amylase or lipase level superior in three-fold respective laboratory baseline levels, and suitable findings in imaging techniques (CT, ultrasound or MRI)
• 2) age > 18 years, sign consent form.

Exclusion criteria

• 1) pregnant o breastfeeding women;
• 2) abdominal pain lasting >96 horas before admission;
• 3) the possibility of poor oral intake for reasons other than AP;
• 4) Pancreatic neoplasm, endoscopic retrograde cholangiopancreatography or trauma etiology;
• 5) Chronic pancreatitis;
• 6) Randomization greater the 12 hours after admission