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Completed

NCT Number: NCT02325765

Study of the Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery

In this study，the investigators want to determine the corelation between circulating nuclearsome and the development of SIRS occured after congenital cardiac surgery, including the serverity of organ damage and inflamation.

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Key information

Conditions

Congential Cardiac Surgery

Age range

1 month–3 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Shanghai Children's Medical Center

Shanghai, Shanghai Municipality, 200127, China

About this study

Blood was collected from study participants at 6 time points; 1) post-anesthesia induction, 2) post-op hour 0, 3) post-op hour 4, 4) post-op hour 24, 5) post-op hour 48, and 6) post-op hour 72. At each of the 6 time points blood was analyzed for levels of the following:histone,blood routine test , c-reaction protein, procalcitonin, N-terminal pro-brain natriuretic,the hepatorenal function，cardiac function and pulmonary function

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • children with congenial heart disease

Exclusion criteria

  • Less than 2.5kg
  • Prematurity less than 37 weeks estimated gestational age
  • Renal failure as described by the pediatric RIFLE criteria

Treatment and study plan

Primary outcomes

  1. the perioperation change of histone level

    Time frame: preoperation to 72 hours after congential cardiac surgery

Secondary outcomes

  1. the perioperation change of c-reaction protein level

    Time frame: preoperation to 72 hours after congential cardiac surgery

  2. the perioperation change of cardiac function

    Time frame: preoperation to 72 hours after congential cardiac surgery

  3. the perioperation change of blood routine test

    Time frame: preoperation to 72 hours after congential cardiac surgery

Sponsors and collaborators

Lead sponsor

Shanghai Children's Medical Center

Other

Registry information

Official study title

Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Dec 25, 2014
Registry last updated
Dec 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.