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Completed

NCT Number: NCT02502474

Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne

Epidemiological study aiming to describe the carriage (nasal, throat, groin, rectal and colonic) of S. aureus in patients without chronic digestive disease who are going to have a colonoscopy for cancer screening. The carriage will be analyzed globally and the similarity of strains isolated from each site will be analyzed using molecular tools. The aim of this study is to better estimate the digestive reservoir of S. aureus to better prevent endogenous infections due to this bacterium.

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Key information

Conditions

Staphylococcal Infections Bacterial Infections Bacterial Infections and Mycoses Gram-Positive Bacterial Infections Infections

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Saint-Etienne

Saint-Etienne, 42055, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient affiliated to French social security
  • Written consent of the patient
  • Patient needing a colonoscopy in the University Hospital of Saint-Etienne, France

Exclusion criteria

  • Patient who decline to participate to the study
  • Patient in the incapacity to give consent
  • Patient receiving treatment with anticoagulant or antiaggregant platelets
  • Patients with a known haemostatic disorder
  • Pregnant woman
  • Patients with a chronic disease of the gastrointestinal tract
  • Patients receiving long-term corticosteroid
  • Patient receiving anti staphylococcal antibiotics

Treatment and study plan

Staphylococcus aureus carriage

Other

nasal, throat, rectal and groin sampling with swabs. Colonic sampling by colonic biopsy

Primary outcomes

  1. Number of patient with Staphylococcus aureus colonic carriage

    Time frame: Day 1

    Staphylococcus aureus carriage in the colon is measured by biopsy

Secondary outcomes

  1. Number of patient with similar Staphylococcus aureus strains in the nose and in the rectum

    Time frame: Day 1

    Staphylococcus aureus carriage in the rectum and in the nose is measured by swab culture

  2. Number of patient with Staphylococcus aureus carriage in the nose

    Time frame: Day 1

    Staphylococcus aureus carriage in the nose is measured by swab culture.

  3. Number of patient with Staphylococcus aureus carriage in the throat

    Time frame: Day 1

    Staphylococcus aureus carriage in the throat is measured by swab culture.

  4. Number of patient with Staphylococcus aureus carriage in the groin

    Time frame: Day 1

    Staphylococcus aureus carriage in the groin is measured by swab culture.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Official study title

Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne.

Acronym: ColoStaph

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Jul 20, 2015
Registry last updated
Sep 28, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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