Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization

This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.

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Key information

Conditions

Rheumatoid Arthritis Arthritis Arthritis, Rheumatoid Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Joint Diseases Mouth Diseases Musculoskeletal Diseases Periodontal Diseases Periodontitis Rheumatic Diseases Skin and Connective Tissue Diseases Stomatognathic Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants included in the genome-wide association study (GWAS) database.
Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.

Exclusion criteria

Individuals without complete genotypic data or those with missing critical phenotypic information.

Treatment and study plan

Primary outcomes

Causal Association Between Rheumatoid Arthritis and Periodontitis

Time frame: Data collected from 2023 to 2024.

This study uses Mendelian randomization to evaluate the causal relationship between rheumatoid arthritis (RA) and periodontitis in the East Asian population. The analysis utilizes genome-wide association study (GWAS) data, employing inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess the genetic relationship and the risk contribution of RA to the development of periodontitis.

Secondary outcomes

Analysis of Genetic Pleiotropy and Confounders

Time frame: 2023 to 2024

Evaluation of the presence of genetic pleiotropy and its potential effect on the association between rheumatoid arthritis and periodontitis.

Sponsors and collaborators

Lead sponsor

Zhibin Xu

Other

Collaborators

Zhongshan People's Hospital, Guangdong, China

Registry information

Official study title

Causal Association Between Rheumatoid Arthritis and Periodontitis: A Mendelian Randomization Study

Acronym: RAPD-MR

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Sep 19, 2024
Registry last updated: Sep 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed