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NCT Number: NCT05660733

Study of the Aortic and Large Arterial Vessel Infections

Aortic or large arterial vessel infections are rare but serious infections. Their management is based on French and American expert opinions. The quality of evidence supporting these guidelines is low because most publications on the subject correspond to case series and few interventional studies have been performed to validate their management. However, referral centres for vascular surgery are frequently solicited to give their opinion on patients suffering from mycotic aneurysms. In addition, the last few decades have seen the improvement of vascular surgery techniques allowing the management of more and more patients, often elderly and comorbid. There has therefore been an increase in the incidence of infectious complications associated with this care. It is therefore essential to participate in research on aortic and large arterial vessel infections. For this, a monocentric cohort study seems to be an essential first step to better understand the polymorphism and complexity of these patients.

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Key information

Conditions

Aortic Infections and Inflammations Aneurysm Aneurysm, Infected Arterial Infections and Inflammations Cardiovascular Diseases Infections Inflammation Mycotic Aneurysm Pathologic Processes Pathological Conditions, Signs and Symptoms Prosthetic Infection Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Université de Lorraine, CHRU Nancy and APEMAC

Vandœuvre-lès-Nancy, Lorraine, 54511, France

Location status: Recruiting

Location contact

Lefevre Benjamin, M.D.

CONTACT

[email protected]

+33383157654

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Aortic or large arterial vessel infection. The diagnosis is made on a number of criteria in favour of the diagnosis (at least 2 of the following 3 criteria):
  • Compatible clinical presentation: local or general inflammatory signs suggestive of a deep infection (fever, chills, scar discharge, fistula, febrile abdominal pain and low back pain, ...) or per-operative finding of an infection in contact with native or prosthetic vascular tissue
  • And/or biological (inflammatory syndrome) and/or imaging evidence (infectious sign on native, bioprosthetic or prosthetic vascular tissue on CT and/or PET scan) in favour of the diagnosis
  • And/or microbiological evidence (positive serologies, blood cultures or deep samples in favour of infection)

Exclusion criteria

  • Patient who objected to participation in this protocol and data collection
  • Pregnant woman, parturient or breastfeeding mother
  • Person deprived of liberty by a judicial or administrative decision,
  • Person subject to psychiatric care by virtue of articles L.3212-1 and L.3213-1 of the French public health code
  • Person subject to a legal protection measure
  • Person unable to give consent

Treatment and study plan

Primary outcomes

  1. one-year mortality

    Time frame: one year after the diagnosis

    Study of all-cause mortality in patients with aortic vascular infection and large arterial vessels during the first year of follow-up after diagnosis.

Secondary outcomes

  1. Identification of prognostic factors associated with arterial vascular infections

    Time frame: at the time of diagnosis and up to one year afterwards

    Identification of prognostic factors in patients with aortic and large arterial vessel infection: a multivariate Cox model to identify factors associated with mortality or better survival

Study contacts

Contact information is provided by the study sponsor or research team.

Lefèvre Benjamin, M.D.

CONTACT

[email protected]

+33383157654

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

French Registry Studying the Characteristics and Prognosis of Aortic and Large Arterial Vessel Infections

Acronym: Repia

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Dec 21, 2022
Registry last updated
Aug 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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