Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)

Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.

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Key information

Conditions

Stiffness, Aortic Athletes Cardiac Remodeling, Ventricular Magnetic Resonance Imaging, Functional Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Vascular Remodeling Ventricular Remodeling

Age range

18 year–39 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Central Hospital

Nancy, 54000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

to be enrolled in a social security plan.
to have a BMI between 18,5 and 25 kg/m²
to have received full information on the organization of the research and having signed its informed consent
to have carried out a clinical screening adapted to the research

*** Triathlete group:

to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof),
to participate in 2018 in a long distance triathlon, i. e. at least distance L
to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective

***Control group:

to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.).

Exclusion criteria

Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code
Cardiovascular history including Ii.e. known heart rhythm disorders
Chronic disease: diabetes, high blood pressure...
Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist,
Active smoking, even if occasional
Contraindication to MRI

Treatment and study plan

Cardiac MRI

Device

Non injected cardiac MRI exam

Applanation tonometry

Device

Applanation tonometry and ECG

Primary outcomes

Aortic compliance in triathletes in mm2/mmHG

Time frame: at baseline, at the fitness peak (6 to 10 months later) and at recovery (3 to 6 months after the fitness peak)

aortic compliance = pulsed pressure-to-absolute variation of aortic surface ratio

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

Study of the Remodeling of the Ascending Aorta During the Sports Season in Long Distance Triathletes Versus Controls

Acronym: CoATri

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Nov 29, 2017
Registry last updated: Feb 11, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed