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NCT Number: NCT04978948

Study of STIM1 Membrane Expression

The aim of this study is to determine the expression of STIM1 in the plasma membrane of lymphocytes from patients suffering from different autoimmune diseases in order to identify new pathologies of interest presenting an over-expression of STIM1PM.

This would allow to initiate, following this study, research and development programs on the use of anti-STIM1 antibodies in these identified autoimmune diseases of interest.

Recruiting

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Key information

Conditions

Autoimmune Diseases Immune System Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU de Brest - Service de rhumatologie, Brest, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of one of the autoimmune diseases

Exclusion criteria

  • Treatment with rituximab in the previous 12 months

Treatment and study plan

Primary outcomes

  1. level of STIM1-PM

    Time frame: Day 0

    Membrane expression level of STIM1-PM on the surface of immune cells, measured by flow cytometry

Secondary outcomes

  1. correlation between STIM1 expression and Clinical Score

    Time frame: Day 0

    Study of correlation between STIM1 expression on different cells and clinical scores of different autoimmune diseases or treatments received

Study contacts

Contact information is provided by the study sponsor or research team.

Divi Cornec

CONTACT

[email protected]

02 98 22 33 33

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Study of STIM1 Membrane Expression During Autoimmune Diseases

Acronym: STIMEX

Important dates

Study start
2021
Primary completion
2027
Study completion
2027
First posted
Jul 27, 2021
Registry last updated
Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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