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OpenTrials
Completed

NCT Number: NCT01765374

Study of Sonographic Efficacy of Rituximab in Rheumatoid Arthritis

To detect by sonography relapse of disease activity prior to clinical symptoms in RA patients treated by rituximab.

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Key information

Conditions

Rheumatoid Arthritis Arthritis Arthritis, Rheumatoid Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Department of Rheumatology, CHU de Caen, Caen, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • failure to at least one TNF-blocking agent

Exclusion criteria

  • pregnant or childbearing woman
  • Rituximab contraindication
  • woman unable to use contraceptive means

Treatment and study plan

ESAOTE MyLab60

Device

US evaluation at different time points

Other names: sonography

Rituximab

Drug

Primary outcomes

  1. global score of power-doppler activity measured by ultrasonography on 12 joints

    Time frame: at 6 months after initiation of rituximab and then every 2 month over the follow-up period (18 months)

    Each time point will be assessed since the main objective of the study is to detect the time of sonographic relapse prior to clinical relapse

Sponsors and collaborators

Lead sponsor

University Hospital, Rouen

Other

Registry information

Acronym: SEWORRA

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Jan 10, 2013
Registry last updated
Apr 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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