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OpenTrials
Completed

NCT Number: NCT04516928

Study of SARS-CoV2 Virus (COVID-19) Seroprevalence Among Lyon-Bron Military Health Schools Personnel

Emerging in China in December 2019, Covid-19, whose pathogen is SARS-Cov-2, was declared a global pandemic in March 2020. The clinical presentation is highly variable, ranging from asymptomatic forms to acute respiratory distress and even death. Transmission is by droplet route, with an R0 of approximately 3.

Rapidly, population protection measures were put in place by governments, including the confinement of all persons whose functions were not considered essential and the closure of educational institutions.

Health care institutions are places at risk of Covid-19 transmission and hospital staff are particularly exposed, either through direct contact with patients, contact with exposed persons or through the environment. In order to protect personnel, hygiene measures were immediately recalled and reinforced.

During the period of containment, the majority of students from the Lyon-Bron Military Medical Schools were sent as reinforcement in Army Training Hospitals and in the Military Reanimation Unit (Mulhouse). Some students developed symptomatic forms of SARS-Cov-2 infection, documented by positive PCR, during Operation Resilience or on their return from the mission.

The Lyon-Bron Military Medical Schools staff, exposed both to the initial phase of the epidemic and to national protection measures, represent an extremely interesting population for understanding the epidemiological dynamics of the virus.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Antenne Médicale des Ecoles Militaires de Santé de Lyon-Bron (EMSLB)

Bron, 69675, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • at least 18 years of age
  • personnel of the Military Health Schools of Lyon-Bron
  • working at the Military Health Schools of Lyon-Bron during the COVID-19 crisis

Exclusion criteria

  • under 18
  • contraindication to blood sampling

Treatment and study plan

Anti-SARS-CoV2 Serology

Diagnostic Test

The anti-SARS-CoV2 serological status will be measured on a blood sample collected at Day 0.

Questionnaire

Other

A questionnaire on socio-demographical status, health status and lifestyle habits during the pandemic will be filled by the participants at Day 0.

Primary outcomes

  1. Proportion of anti-SARS-CoV2 seropositive participants

    Time frame: Day 0

    The proportion of anti-SARS-CoV2 seropositive participants will be determined. ELISA serology test will be used to detect anti-SARS-CoV2 antibodies (IgG and IgM) at Day 0.

Secondary outcomes

  1. Proportion of asymptomatic participants (among anti-SARS-CoV2 seropositive participants)

    Time frame: Day 0

    The proportion of asymptomatic participants (among anti-SARS-CoV2 seropositive participants) will be determined. COVID-19 symptoms will be measured using a questionnaire.

  2. Correlation coefficient between medical risk factors and a positive serology

    Time frame: Day 0

    Correlation coefficient between medical risk factors and a positive serology will be assessed using a step-by-step top-down regression analysis.

  3. Correlation coefficient between epidemiological risk factors and a positive serology

    Time frame: Day 0

    Correlation coefficient between epidemiological risk factors and a positive serology will be assessed using a step-by-step top-down regression analysis.

  4. Correlation coefficient between social risk factors and a positive serology

    Time frame: Day 0

    Correlation coefficient between social risk factors and a positive serology will be assessed using a step-by-step top-down regression analysis.

Sponsors and collaborators

Lead sponsor

Direction Centrale du Service de Santé des Armées

Other

Registry information

Acronym: SeroCovEms

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Aug 18, 2020
Registry last updated
Mar 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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