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Completed

NCT Number: NCT03421847

Study of Rotatory Vestibular Tests in Major Depression Patients and Healthy Control Subjects.

This study evaluates the vestibular activity in major depression patients and healthy controls using the rotatory test and electronystagmography.

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Key information

Conditions

Depression Behavior Behavioral Symptoms Ear Diseases Labyrinth Diseases Otorhinolaryngologic Diseases Vestibular Diseases Vestibular Disorder

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Previous studies showed abnormal vestibular activity in major depression patients using caloric vestibular tests. The present study investigates the vestibular response to vestibular rotatory tests in major depression subjects and healthy controls.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male and females adults (18 years or older)
  • met the Diagnosing and Statistical Manual of Mental Disorders (DSM-IV-R, American Psychiatric Association, 2000) criterion.
  • had a score of 12 or more in the Hamilton Rating Scale, 21 items for Depression.
  • with or without actual pharmacological treatment, except benzodiazepines that were suspended 24 hours before the rotary test when corresponding.

Exclusion criteria

  • pregnant women
  • neurologic disorders.

Treatment and study plan

Rotatory vestibular test

Diagnostic Test

We will measure Depression and Healthy subjects vestibular activity by Rotatory Vestibular tests

Primary outcomes

  1. Vestibular Activity

    Time frame: Vestibular rotatory test for each participant is about 50- 60 minutes. One rotatory test per participant.

    The primary outcome corresponds to the vestibular activity. The vestibular stimulation provided by the rotatory chair is sensed by the inner ear´s vestibular receptors and generates reflex ocular movements(Vestibulo Ocular Reflex) registrated by electronystagmography. The main outcome corresponds to the asymmetry of the vestibular activity between both ears.

Sponsors and collaborators

Lead sponsor

Vest Brain,Centro de Estudios Neurovestibulares

Other

Collaborators

  • Centro de Medicina Aeroespacial.

Registry information

Important dates

Study start
2005
Primary completion
2006
Study completion
2006
First posted
Feb 5, 2018
Registry last updated
Feb 6, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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