Study of Remimazolam Tosilate in Patients Undergoing Diagnostic Upper GI Endoscopy

This is a multi-center, ,parallel-group, single blind study using Remimazolam or propofol for sedation in patients undergoing diagnostic upper GI endoscopy.Subjects are randomized to different treatment groups (including 1 for Remimazolam Tosilate and 1 for propofol). Fentanyl are permitted during a diagnostic upper GI endoscopy.Efficacy and safety profiles of Remimazolam Tosilate are to be evaluated.

Inclusion criteria

• subjects aged 18-60 years；
• intending to undergo diagnostic upper GI endoscopy;
• ASA( American Society of Anesthesiologists) I or II；
• 18 kg/m²<BMI(Body Mass Index)<30 kg/m²;
• the operation time of gastroscopy is not more than 30 min；
• Signed informed consent.

Exclusion criteria

• Patients need to be Complicated gastroscopy;
• Patients need to be Tracheal intubation;
• Patients with respiratory management difficulties (Modified Mallampati grade IV）;
• one or more of the laboratory findings fall out of the limitations for this study(platelet,hemoglobin,aspartate aminotransferase,etc.);
• A history of drug abuse and / or alcohol abuse 2 years prior to the screening period；
• allergic to drugs used in the study;
• pregnant women or those in lactation period
• The subject has participated in other clinical trial within the 3 months prior to randomization.