Study of Placental Function in Healthy and Pathological Pregnancies

The purpose of this study is to establish a tissue and data repository consisting of samples of human placentas, umbilical cord blood, and maternal blood, collected at the time of delivery. Specimens will be used in cellular, molecular, and functional studies to learn more about changes in placental structure and function, which can result in serious pregnancy complications and determine life-long health by programming the fetus for future metabolic and cardiovascular disease.

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Key information

Conditions

Pregnancy

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

University of Colorado Hospital

Aurora, Colorado, 80045, United States

Location status: Recruiting

Location contact

Anita Kramer

CONTACT

[email protected]

303-724-1653

Thomas Jansson, MD, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy women delivering at term
Women with pregnancy complications such as:

pre-term birth,
intrauterine growth restriction,
diabetes, and
obesity.

Exclusion criteria

Women:

under stress,
experiencing pain of labor.
Pregnancies complicated by other pathologies.

Treatment and study plan

Primary outcomes

Collecting, processing, and archiving human specimens from 1250 subjects

Time frame: Specimens will be stored for 50 years in repository

Human placental tissue, umbilical cord blood, and maternal blood samples will be collected from pregnant women at the time of their delivery. The samples will be used to enhance understanding of the role of the placenta in the development of pregnancy complications and in programming of adult disease.

Study contacts

Contact information is provided by the study sponsor or research team.

Anita Kramer

CONTACT

[email protected]

303-724-1653

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2031
Study completion: 2031
First posted: Dec 19, 2014
Registry last updated: Feb 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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