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NCT Number: NCT07535320

Study of Patient Preferences in Dialysis Treatment Choice: a Discrete Choice Experiment

Background Compared to in-center dialysis, home dialysis is associated with better quality of life and lower healthcare system costs. However, barriers remain to its wider adoption. Chronic disease, particularly at an advanced stage, is a major driver of socioeconomic vulnerability. Among dialysis patients, the proportion of individuals covered by France's Universal Health Protection scheme (PUMA) is higher than in the general population. Similarly, those from the most disadvantaged social classes are overrepresented among dialysis patients compared to the overall French population. Dialysis can also lead to job loss. Financial compensation schemes may influence the choice of home dialysis. In France, patients who perform dialysis at home-either independently or with help from a trained family caregiver-are eligible for a "third-person compensatory allowance" (DTP). For some socioeconomically vulnerable patients, eligibility for DTP may influence their decision to opt for home treatment. The DTP is specific to the French healthcare system but could be considered in other countries, particularly within the European Union. Indeed, in most countries with income levels comparable to France, the additional cost of home dialysis is borne by the patient. This study aims to determine whether receiving financial compensation plays a role in choosing a dialysis modality (home-based versus in-center or assisted home dialysis).

Objectives To investigate factors associated with patient preferences regarding renal replacement therapy.

Methods A discrete choice experiment (DCE) was conducted comparing two options: home dialysis (PD and HHD, with DTP) versus in-center hemodialysis (no DTP).

Perspectives If financial compensation influences patients' choices toward home dialysis, the DTP model could be used to address barriers to home-based treatment.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patient
  • Patient with advanced chronic kidney disease receiving pre-surgery information (presentation of methods)
  • Patient enrolled in a social security program
  • Patient able to read and understand French
  • Patient able to complete the questionnaire (cognitive and sensory)

Exclusion criteria

  • Minor patients
  • Patients transitioning from one method of extrarenal purification to another
  • Patients requiring urgent dialysis
  • Patients who cannot read or understand French
  • Patients under legal protection (guardianship, curatorship, judicial protection)

Treatment and study plan

Questionnaire

Other

Patients are given a questionnaire. The first part concerns sociodemographic characteristics. The second part concerns the choice of replacement therapy itself.

Patients must choose between three possible treatments: "If you had to choose a treatment based on the options provided, which one would you choose? Patients make this choice 13 times (the options change).

Primary outcomes

  1. Preference coefficients for renal replacement therapy attributes, including monthly financial allowance, estimated using a discrete choice experiment

    Time frame: Baseline (during the single discrete choice experiment assessment at study enrollment)

    Participants will complete 13 discrete choice tasks, each requiring selection of one preferred scenario among three renal replacement therapy options. Scenarios are defined by combinations of five attributes: schedule flexibility, nurse availability, dialysis frequency, timing of sessions, and monthly financial allowance.

    Preferences will be analyzed within a random utility framework using a mixed logit model. The primary outcome is the estimation of marginal utilities (preference coefficients) associated with each attribute level. Particular focus will be placed on the coefficient associated with the monthly financial allowance attribute, to assess its influence on the probability of choosing a home-based treatment modality.

    This approach allows indirect elicitation of patient preferences without explicit ranking, consistent with economic theory of revealed preferences.

Study contacts

Contact information is provided by the study sponsor or research team.

Clémence Tomadesso, Mrs

CONTACT

[email protected]

+33231063106

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Registry information

Acronym: PREFDOM

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 17, 2026
Registry last updated
Apr 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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