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Completed

NCT Number: NCT02574182

Study of Motor Representations in Healthy Subjects and Amnestic MCI

Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.

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Key information

Conditions

Mild Cognitive Impairment Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Angers

Angers, Pays de la Loire Region, 49933, France

About this study

Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (<40 years and> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obtaining the signature of consent to participation in the study
  • Age above 18 years
  • Lack dementia as NICDS-ADRDA criteria
  • Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI).
  • Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae.
  • No cons-indication for performing a brain MRI.
  • Witennses, population of young (<40 years)
  • Witnesses ,population of older subjects (> 60 years)
  • Witnesses Lack of MCI
  • MCI patients, criteria MCI criteria according to Dubois

Exclusion criteria

  • Refusal of MRI.
  • Contraindications to brain MRI.

Treatment and study plan

brain MRI

Radiation

Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures.

Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk.

The GAITRite is a carpet for recording the walking operating parameters

Other names: KORVIT, GAITRite

Primary outcomes

  1. Review and compare mapping cerebral activation in brain MRI

    Time frame: One day

    Review and compare mapping brain activation in healthy about MRI according to age (<40 years and> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters.

Secondary outcomes

  1. Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking.

    Time frame: One day

    Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters

  2. Study of differences in terms of activation of brain mapping

    Time frame: One day

    Study of differences in terms of activation of brain mapping between mechanical stimulation task arch simulating the place of the step (pace to 120 steps per minute) and a random mechanical stimulation (not reproducing the place of the pitch) . the secondary endpoint will be the analysis of spatiotemporal gait parameters

  3. study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI.

    Time frame: One day

    study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. the secondary endpoint will be the analysis of spatiotemporal gait parameters

  4. study of the potential effects on muscle activation, and autonomic nervous system

    Time frame: One day

    study of the potential effects on muscle activation, and autonomic nervous system of plantar mechanical stimulation reproducing walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters

Sponsors and collaborators

Lead sponsor

University Hospital, Angers

Other Gov

Registry information

Official study title

Walking, Brain and Functional Magnetic Resonance Imaging Study of Motor Representations in Healthy Subjects and Amnestic MCI

Acronym: IRMARCHE

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Oct 12, 2015
Registry last updated
Jul 12, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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