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Completed

NCT Number: NCT05455047

Study of Metabolic Connectivity in Drug-resistant Temporal Epilepsy

18F-Fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET) has a high sensitivity for temporal lobe epilepsy (TLE), the most common form of focal epilepsy, with a detection range of 86-90% . Therefore, 18F-FDG PET is a useful tool to identify the epileptogenic zone (ETZ) in the inter-ictal phase of drug-resistant temporal epilepsy during pre-surgical evaluation . Based on stereotactic electroencephalography (SEEG) findings, a correspondence between electrical data and metabolic changes on PET was found at the group level by identifying four different patterns of TLE . As expected, hypometabolism was not limited to the EZ defined by SEEG, but underlay broader epileptic networks . Because of the different electroclinical presentations of TLE, 18F-FDG PET appears to be a very useful tool in these temporal epilepsies. Indeed, it has been recently demonstrated that a gradient of PET hypometabolism from the uninvolved area to the spreading area, then to the epileptogenic area and to the lesion area is observed with consequently a good performance of 18F-FDG PET in defining the EZ .

Therefore, it is interesting to study PET metabolism as a network and not as a combination of regional metabolic measures in epilepsy.

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Key information

Conditions

Epilepsy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

18 year–56 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Nancy's Hospital

Vandœuvre-lès-Nancy, 54511, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with drug-resistant temporal epilepsy with an accurate diagnosis on SEEG
  • Patients with epilepsy who have had a PET/CT scan with 18F-FDG as part of a pre-operative assessment
  • Person having received complete information on the organization of the research and not having objected to the use of these data;
  • Patients affiliated to a social security system

Exclusion criteria

  • Person who has not received full information on the organization of the research and who has opposed the use of this data
  • A person of full age who is the subject of a legal protection measure (guardianship, curatorship, safeguard of justice).
  • A person of full age who is unable to give consent and who is not subject to a legal protection measure

Treatment and study plan

PET-CT at 18F-FDG

Diagnostic Test

PET-CT at 18f6FDG in nuclear medicine departement of Nancy's hospital

Primary outcomes

  1. Metabolic connectivity

    Time frame: 1 month

    Metabolic connectivity of hypometabolic clusters in each temporal epilepsy subgroup defined by IRCA (interregional correlation analysis) and graph theory

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Acronym: EPINE

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jul 13, 2022
Registry last updated
Aug 24, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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