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NCT Number: NCT05840133

Study of Long Non-coding RNA SNHG15 as a Novel Biomarker in HBV Associated HCC

In this study, the investigators will detect the expression of HBV-related HCC biomarker lncRNA SNHG15 in tumor tissues and peripheral blood, to explore the specific molecular markers for the early diagnosis of HBV-related HCC.

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Key information

Conditions

HCC

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

About this study

Paired hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and adjacent liver tissues were selected, and lncRNA SNHG15 was detected by RT-PCR. At the same time, healthy subjects were selected as the control group, and lncRNA SNHG15 in blood was detected by RT-PCR. At the same time, the correlation between lncRNA SNHG15 and the clinical data of patients, such as diagnosis, pathological grading, recurrence, metastasis and survival time was statistically analyzed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The age and sex of the healthy control group were matched with that of HBV-associated patient group. There was no tumor in the other parts of the body, and no tumor in the blood system. The healthy control group did not have any liver benign diseases. There are no inflammatory diseases in other parts of the body; the functions of the liver, kidney, and heart were normal.

Exclusion criteria

  • The volunteer has tumors in the liver or other parts of the body, or blood system tumors; The volunteer has benign liver diseases; The patient has inflammatory disease elsewhere. If the volunteer has any one of the above diseases, it shall be excluded.

Treatment and study plan

No intervention was required for patients or control group in this study

Diagnostic Test

The patient was treated normally and no intervention was required in this study

Primary outcomes

  1. Detection of lncRNA SNHG15 in HBV-associated HCC patients before surgery

    Time frame: 1 to 3 days before surgery

    The expression of lncRNA SNHG15 in blood samples: The expressions of lncRNA SNHG15 in blood samples were detected by real-time fluorescence quantitative PCR method.

Secondary outcomes

  1. Detection of lncRNA SNHG15 in HBV-associated HCC patients 1 week after surgery

    Time frame: one week after surgery

    • The expressions of lncRNA SNHG15 in tissues: In the tumor and adjacent tissues from HBV-associated HCC patients, the expressions of lncRNA SNHG15were measured by real-time fluorescence quantitative PCR method.
    • The expression of lncRNA SNHG15 in blood samples: The expressions of lncRNA SNHG15 in blood samples were detected by real-time fluorescence quantitative PCR method.

  2. Detection of lncRNA SNHG15 in HBV-associated HCC patients at 6 months after surgery

    Time frame: 6 months postoperatively

    The expression of lncRNA SNHG15 in blood samples: The expressions of lncRNA SNHG15 in blood samples were detected by real-time fluorescence quantitative PCR method.

  3. Detection of lncRNA SNHG15 in the control groups as baseline

    Time frame: the level of lncRNA SNHG15 were detected as baseline

    The expression of lncRNA SNHG15 in blood samples: The expressions of lncRNA SNHG15 in blood samples were detected by real-time fluorescence quantitative PCR method.

Study contacts

Contact information is provided by the study sponsor or research team.

Chunqing Wang, Dr.

CONTACT

[email protected]

053189269680

Sponsors and collaborators

Lead sponsor

Qianfoshan Hospital

Other

Registry information

Official study title

The First Affliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital

Important dates

Study start
2023
Primary completion
2025
Study completion
2027
First posted
May 3, 2023
Registry last updated
May 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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