Montpellier University Hospital
Montpellier, 34000, France
Location status: Recruiting
Recruiting
NCT Number: NCT06484387
Study of Intra- and Interpersonal Multimodal Synchronizations in a Social Interaction in Individuals with a Diagnosis of Schizophrenia.
The aim of this study is to precisely identify deficits in intra- and interpersonal multimodal synchronizations during social interaction in individuals with schizophrenia (ISZ). During a social interaction, individuals use both visual and auditory channels to construct their discourse. The auditory channel encompasses the semantics and prosody of the speech, while the visual channel describes the entirety of non-verbal gestures (e.g., facial expressions, body movements). Prosody and non-verbal gestures are essential elements for the speaker. By accompanying speech, they contribute to the planning and conceptualization of the utterance and enhance its communicative power. For the listener, prosody and non-verbal gestures are also used to provide sensory feedback to the speaker.
Several studies have shown the existence of intrapersonal and interpersonal synchronizations of prosody and non-verbal gestures during interaction. These synchronizations are associated with numerous social benefits (e.g., increased mutual appreciation and quality of interaction). However, certain mental disorders, such as schizophrenia, exhibit deficits in non-verbal behaviors that can impair these synchronizations and the associated social benefits. We hypothetized that interaction with individuals with a daignosis of schizophrenia will be associated with deficits in intra and interpersonal synchronization.
Recruiting
Interested in participating?
Request InfoKey information
Age range
18 year–60 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
About this study
This study includes a pre-inclusion interview followed by a visit to the university hospital (CHU) lasting about 2 hours (including a break). During the visit, the patient participates in an experimental protocol consisting of two parts. In the first part, the patient will be paired with an interaction partner, and the two participants will engage in four distinct conversational tasks, including getting to know each other, free discussions, structured dialogues, and emotional interactions. In the second part, the participants will answer several questionnaires and perform neuropsychological tests in collaboration with an experimenter
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Individuals with a diagnosis of schizophrenia :
Inclusion criteria
- diagnosis of schizophrenia according to the DSM-V
- being able to read, speak and understand french
- giving eclaired consent
Exclusion criteria
- history of head trauma
- history of neurological conditions (epilespsy, multiple sclerosis, parkinson's disease, amyotrophic lateral sclerosis, huntington's disease, stroke)
- substance use
- pregnant women
Healthy controls :
Inclusion criteria
- being able to read, speak and understand french
- giving eclaired consent
Exclusion criteria
- diagnosis of psychosis
- history of head trauma
- history of neurological conditions (epilespsy, multiple sclerosis, parkinson's disease, amyotrophic lateral sclerosis, huntington's disease, stroke)
- substance use
- pregnant women
Treatment and study plan
social interaction
BehavioralParticipants are required to speak to one another. Participants are given various topics of conversation.
Primary outcomes
-
interpersonal synchronization
Time frame: 4x6 minutes
synchronization between body movements of two interacting partners
-
intrapersonal synchronization
Time frame: 4x6 minutes
synchronization between voice and body movements of one individual
Secondary outcomes
-
correlation between primary outcomes and individuals with schizophrenia medications
Time frame: 4x6 minutes
-
correlation between synchronization and willingness to continue the interaction
Time frame: 4x6 minutes
Study contacts
Contact information is provided by the study sponsor or research team.
Delphine Capdevielle, Pr
CONTACT
Mathilde Parisi
CONTACT
Sponsors and collaborators
Lead sponsor
University Hospital, Montpellier
Other
Collaborators
- Euromov Digital Health in Motion
Registry information
Official study title
Study of Multimodal Intra- and Interpersonal Synchronizations in Social Interaction in Individuals with a Diagnosis of Schizophrenia.
Acronym: ENHANCER1
Important dates
- Study start
- 2024
- Primary completion
- 2025
- Study completion
- 2025
- First posted
- Jul 3, 2024
- Registry last updated
- Dec 9, 2024
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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