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Completed

NCT Number: NCT01613911

Study of Human Sensory Perception

This study will help describe how the human brain works when a person sees something, hears something, learns something, or thinks about something by recording brain activity that occurs when the person does a series of computer tasks. This study will be offered to people who are in the hospital to be monitored for epilepsy by using electrodes placed in the brain. The study will record brain activity that occurs when a patient does a memory task, for example.

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Key information

Conditions

Epilepsy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

10 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Swedish Medical Center Epilepsy Center

Seattle, Washington, 98122, United States

About this study

Patients who have elected to have invasive electrophysiological monitoring for epileptic activity are invited to participate in this study. While the electrodes are in place, patients are asked to view several scenarios on a laptop computer. During these scenarios, for example, patients are asked to click a mouse button if they see the same picture twice in a row or to remember a film clip of a scooter ride. Trigger points in the computer scenarios are recorded on a separate channel alongside the brain-wave activity to allow correlation between the brain activity and the task requested in the scenario. Using this technique, researchers can determine what areas of the brain were active during recognition or recall activities.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Primary diagnosis of epilepsy
  • Between 10 and 65 years of age
  • Scheduled to undergo invasive electrophysiological monitoring as part of a clinical evaluation for epilepsy treatment

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. Reveal induced neuronal activity

    Time frame: Approximately 3 hours over the course of 2-3 days during in-patient invasive electrophysiological monitoring.

    In the preprocessing stage, potential electrical interference will be removed from the raw signal using a linear-phase notch FIR filter. Each electrode will be de-referenced by subtraction of the averaged signal of all the electrodes, thus discarding non-neuronal contributions. Time-frequency decompositions will be calculated for each electrode based on Fourier transform amplitude spectrum in a 160ms sliding window with average step size of 6ms. This process is done per trial and averaged across trials in order to reveal induced neuronal activity, which is not time-locked to the stimuli.

Secondary outcomes

  1. Calculate evoked response potentials.

    Time frame: Approximately 3 hours over the course of 2-3 days during in-patient invasive electrophysiological monitoring.

    Evoked response potentials (ERPs) will be calculated by averaging the raw signal across the presentation of a specific stimulus for each patient, such as all samples of patients watching the movie clip.

Sponsors and collaborators

Lead sponsor

Swedish Medical Center

Other

Collaborators

  • Weizmann Institute of Science

Registry information

Official study title

A Combined fMRI and Electrophysiological Study of Human Sensory Perception

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Jun 7, 2012
Registry last updated
Dec 8, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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