Study of Hemodynamic Conditions Measured During Hepatectomy

Hepatocellular insufficiency is a dreaded complication after hepatectomy, since, if it is persistent, it leads to the death of the patient in the absence of liver transplantation.

The preoperative evaluation aims in particular to estimate the risk of postoperative hepatocellular insufficiency so as to minimize or contraindicate high-risk patients.

It has been shown that the flow of the portal vein is correlated with liver function, especially in the living donor and after portal embolization. More recently, the study of flow rates in the portal vein and the hepatic artery after transplantation has shown a correlation with the recovery of graft function.

The hypothesis is that portal and arterial flow after hepatectomy can predict postoperative hepatocellular function.

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Key information

Conditions

Liver Dysfunction Circulatory; Change Digestive System Diseases Liver Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de Chirurgie Digestive, Oncologique, Endocrinienne et Transplantation Hépatique, CHRU de TOURS

Tours, 37044, France

About this study

Measurements of flow rates in the portal vein and the hepatic artery by different transit times are available thanks to the Medistim VeriQTM system that the investigators already use routinely in the context of liver transplantation when performing hepatectomies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patient 18 years or more
Patient undergoing laparotomy for liver resection

Exclusion criteria

Patient under tutorship or curatorship
Pregnant or lactating woman
Difficulties in understanding French
Patient operated by laparoscopy
Patient having objected to the processing of his data

Treatment and study plan

Liver debit measure

Procedure

Mesure of liver debit during hepatectomy

Primary outcomes

Liver vessel debit

Time frame: Baseline

Mesure of liver debit during hepatectomy

Sponsors and collaborators

Lead sponsor

University Hospital, Tours

Other

Registry information

Acronym: DEBIFOIE

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Dec 13, 2017
Registry last updated: Mar 18, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed