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NCT Number: NCT03867448

Study of Endocrine-Related Conditions and Physiology

Background:

Endocrine disorders involve changes to glands that produce hormones. Hormones are released by these glands into the blood so they can direct the function of other tissues in the body. Researchers want to study people who may have endocrine disorders. They want to learn more about the conditions that affect endocrine glands.

Objective:

To study adults with a variety of endocrine disorders for research and physician education.

Eligibility:

Adults ages 18 and older who have an endocrine or metabolic-related disorder

Healthy volunteers 18 and older

Design:

Participants will be screened with a review of their medical records.

Participants will have a physical exam and medical history.

The length of the study and the schedule will vary by participant. Tests may include:

Blood and urine tests

Stool and saliva samples

Imaging studies: Participants will lie on a table while a machine takes pictures of the body. They may be injected with a substance to make their organs more visible in the pictures.

Tests of endocrine tissue function

Consultation with other specialists

Sleep study

Medical photographs

Participants may be treated for their endocrine disorder. This could include:

Surgery. If tissue is removed during surgery, it may be studied.

Radiation

Medicine

Participants may have genetic testing. This will be done with a small amount of blood, cells from a cheek swab, or saliva.

Sponsoring Institution: National Institute of Digestive, Diabetes and Kidney Disease

Recruiting

Interested in participating?

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Key information

Conditions

Endocrine Disease Brain Diseases Central Nervous System Diseases Endocrine System Diseases Hypothalamic Diseases Nervous System Diseases Pituitary Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

Location status: Recruiting

Location contact

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

CONTACT

[email protected]

800-411-1222 ext. TTY8664111010

About this study

Study Description:

This study allows the NIH Intramural Endocrinology Training Program (IETP) to follow or provide evaluation, treatment and or interventions to certain eligible subjects.

Objectives:

  • To provide a repository of data and samples obtained during the course of clinical care to allow for future research.
  • To add value to the IEFP training program by maintaining a diverse group of endocrine conditions seen at the NIH.
  • To provide a vehicle by which pilot studies of endocrine physiology can be initiated.
  • To identify prismatic cases that deviate from known presentations or responses to treatment.
  • To evaluate the safety and results from adrenal venous sampling using a modified catheter with side hole placement.

Endpoints:

  • Data from standard of care evaluation and management.
  • Adverse events during and after adrenal vein sampling; cortisol and aldosterone results from the sampling.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all the following criteria:

  • Adult men and women age 18 years or older.
  • Known or suspected endocrine disorders requiring clinical screening, management and/or treatment and follow-up.
  • Stated willingness to comply with all study procedures and availability for the duration of the study

Exclusion criteria

  • Unstable participants and participants with severe organ failure, or those with a condition or medical treatment that may affect/limit the endocrine work-up and exhaust Clinical Center, IETP resources will be excluded if appropriate.
  • Inability of a subject to adhere to a proposed schedule of visits.
  • Inability to provide informed consent.

Treatment and study plan

Creation of side holes in catheters for adrenal vein sampling

Device

one or two side-holes will be created by the interventional radiologist to facilitate adrenal vein sampling

Primary outcomes

  1. Diagnosis/Treatment

    Time frame: variable

    determination of diagnosis and/or treatment of an endocrine disorder

Study contacts

Contact information is provided by the study sponsor or research team.

Lynnette K Nieman, M.D.

CONTACT

[email protected]

(301) 496-8935

Raven N McGlotten, R.N.

CONTACT

[email protected]

(301) 827-0190

Sponsors and collaborators

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Nih

Registry information

Official study title

The Evaluation and Management of Endocrine-Related Conditions and Physiology

Important dates

Study start
2019
Primary completion
2036
Study completion
2036
First posted
Mar 8, 2019
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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