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Completed

NCT Number: NCT07133204

Study of Efficacy and Safety of Cream Infused With HuangQin (Root of Scutellaria Baicalensis) Extract for the Reduction of Hyperpigmentation

The aim of this study is to evaluate the efficacy of a topical cream infused with Scutellaria baicalensis extract in reducing hyperpigmentation on the face.

The study is experimental clinical pilot study as a single group pretest-posttest.

A ROAT is conducted 1 week prior to the experiment. Participant apply the cream on the hypigmented area daily. Facial skin parameters (i.e. melanin index, erythema index) is evaluated at week 0, 1, 2 and 4.

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Key information

Conditions

Hyperpigmentation; Melanin Hyperpigmentation Pigmentation Disorders Skin Diseases Skin and Connective Tissue Diseases

Age range

30 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mae Fah Luang University

Muang, Changwat Chiang Rai, 57100, Thailand

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or Female
  • Has at least 1 hyperpigmentation spot (size > 3mm) on either side of the face
  • 30-60 y/o
  • Fitzpatrick skin types II-IV
  • Agrees to use sunscreen SPF50+ and willing to avoid strong sunlight exposure during the study

Exclusion criteria

  • Pregnant or lactating
  • Use of whitening products or treatment within 1 month before this study
  • Currently using contraceptives
  • History of allergy to any ingredient in the intervention cream
  • Has skin conditions which can interfere with the measurement (i.e. severe acne, eczema, herpes simplex)
  • Severe disease (i.e. immunodeficiency, cancer)
  • Enrolled in other clinical study within 3 month before this study

Treatment and study plan

Investigator developed cream infused with HuangQin extract

Other

A water in oil emulsion with consistency similar to cold cream. Infused with organic extract of scutellaria baicalensis.

Primary outcomes

  1. Efficacy of hyperpigmentation reduction property of the intervention

    Time frame: Week 0, 1, 2 and 4

    Measured the melanin index of the hyperpigmented area

  2. Safefty profile of the intervention

    Time frame: Week 1, 2 and 4

    Record and collect the adverse effect from the usage of the interventional cream

Secondary outcomes

  1. Efficacy of erythema reduction property of the intervention

    Time frame: Week 0, 1, 2 and 4

    Measured the erythema index of the hyperpigmented area

  2. Efficacy of skin hydration property of the intervention

    Time frame: Week 0, 1, 2 and 4

    Measured the skin hydration value of the hyperpigmented area

Sponsors and collaborators

Lead sponsor

Mae Fah Luang University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 20, 2025
Registry last updated
Aug 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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