Study of Arterial Recanalization of the Central Retinal Artery Occlusions

Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke (IS) at the retinal level. They share the same risk factors and common pathology. Their incidence is lower (8.5 / 100,000) and the functional prognosis is unfavorable in 80% of cases with visual acuity (VA) <1/10. The diagnosis of an CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia. There is no data on early retinal arterial recanalization after CRAO, nor on the relationship between early recanalization (spontaneous or post-thrombolysis) and visual prognosis.

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Key information

Conditions

Central Retinal Artery Occlusion Arterial Occlusive Diseases Cardiovascular Diseases Eye Diseases Retinal Artery Occlusion Retinal Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation ophtalmique Adolphe de Rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Central Retinal Artery Occlusion ≤ 24 hours

Exclusion criteria

Retinal Dynamic angiography not performed within 48 hours of onset of symptoms
Occlusion of a branch of the central retinal artery

Treatment and study plan

Primary outcomes

Dynamic retinal angiography data at 24 hours (+/- 24 hours)

Time frame: 24 hours (+/- 24 hours) following the beginning of symptoms

Proportion of patients with early arterial recanalization.The recanalization rate will be compared between thrombolysed patients and non-thrombolysed patients

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: RECANAL

Important dates

Study start: 2016
Primary completion: 2022
Study completion: 2022
First posted: Feb 10, 2017
Registry last updated: Apr 14, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed