NCT Number: NCT06923202
Study of Alloknesia in Atopic Dermatitis
Alloknesia is defined as pruritus (= itching) triggered by light mechanical stimuli, which are responsible for the perception of light touch under physiological conditions, but which are perceived as pruritic under pathological conditions. Alloknesia occurs mainly in the context of chronic pruritus. Consequently, patients suffering from chronic pruritus frequently perceive light touch sensations as pruritic, which can be particularly unpleasant and alter human interactions and quality of life on a daily basis. However, the epidemiology and burden of alloknesia have never been studied, whatever the cause of chronic pruritus.Atopic dermatitis is one of the main diseases causing chronic itching, and patients frequently complain of alloknesia. In this study, the investigators are studying the frequency of alloknesia in patients with atopic dermatitis and measuring the consequences of alloknesia in these patients.
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Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
CHU d'Angers, Angers, France
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Age ≥18 years
- No opposition from the patient
- Diagnosis of atopic dermatitis more than 6 months old
Exclusion criteria
- Patients who are physically or mentally unable to complete the questionnaires.
- Patients on systemic treatment for 1 month or more
- Refusal to participate
- Patients under legal protection (guardianship, curatorship)
- Patients under court protection
Treatment and study plan
Primary outcomes
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Alloknesia diagnostic questionnaire
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
The questionnaire consists of a single question: 'Can the touch of your skin by clothing, air movements or the light touch of an object or another person trigger itching?
Secondary outcomes
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WI-NRS scale / Worst Itch Numeric Rating Scale
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
Digital pruritus scale, measuring the worst daily itching intensity 0 to 10. 0: no itching 10: worst itch imaginable
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ItchyQoL questionnaire / quality-of life instrument for pruritus
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
Quality-of life instrument for pruritus Itch-related quality of life 0 to 110
-
DLQI questionnaire / Dermatology Life Quality Index
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
Skin-related quality of life 0 to 30
-
HADS questionnaire / Hospital Anxiety and Depression Scale
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
The HAD scale is an instrument for screening for anxiety and depressive disorders.
0 to 21
-
PUSH-D questionnaire / Patient Unique Stigmatization Holistic tool in dermatology
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
PUSH-D allows a comprehensive view of the degree of stigmatization in visible skin disorders.
0 to 68
-
Stress perçu : PSS / Perceived Stress Scale
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
The PSS (Perceived Stress Scale) is a scale for measuring perceived stress. 0 to 40
-
Epworth questionnaire / sleepiness scale
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
The Epworth Test is a self-administered questionnaire that assesses subjective sleepiness and fatigue.
0 to 21
-
ISS questionnaire / Sexual Satisfaction Index
Time frame: At enrollment. If the patient completes the questionnaires at home, they will be brought back by the patient at their next medical consultation.
Satisfaction with sexual relations 25 to 175
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
University Hospital, Brest
Other
Collaborators
- Almirall, S.A.
Registry information
Acronym: ALLOKNESIE
Important dates
- Study start
- 2026
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- Apr 11, 2025
- Registry last updated
- Jun 1, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.