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Completed

NCT Number: NCT01942096

Study of Airway Inflammation in Relation to Exercise in Elite Athletes

High school elite training programs are today more and more under development in several 'elite sport schools' in Belgium, in order to select and train future elite athletes already at young age. Little is known about the effects of sustained training on the potential development of asthma in adolescents during lung growth. It would be of great importance to be able to select the individuals at risk to develop exercise-induced asthma, already at the start of their enrollment in the 'elite sport school. This would allow physicians to follow their lung function parameters very closely and regularly; and, if necessary, start treatment early after the first signs of exercise-induced asthma.

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Key information

Conditions

Exercise Induced Asthma Asthma Asthma, Exercise-Induced Bronchial Diseases Exercise-Induced Allergies Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

14 year–25 year

Sex eligibility

All sexes

Study type

Observational

Primary location

UZ Leuven

Leuven, Vlaams-Brabant, 3000, Belgium

About this study

Competitive swimmers, competitive indoor athletes and control individuals performing sports at a recreational level will be recruited for the study.

They will perform a sport-specific training (swimmers and controls: swimming for 90 minutes, indoor athletes: basketball or volleyball for 90 minutes)

Baseline measurements:

  • Airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), Fraction of exhaled Nitric Oxide measurement and sputum induction.
  • Upper and lower airway symptoms will be assessed by questionnaires (SinoNasal Outcome Measure-22, Visual Analogue Score, Asthma Symptom Score and Juniper Score)
  • Allergy will be assessed by skin prick test (on skin) and immunocap test (in blood, 1 tube of 10 ml).
  • Lung function and nasal patency will be measured by spirometry and Peak Nasal Inspiratory Flow measurement.
  • Exercise induced bronchoconstriction will be assessed by eucapnic voluntary hyperventilation test.

Measurements immediately after training:

  • Collection of nasal fluid
  • Assessment of upper airway symptoms (Visual Analogue Score)
  • Spirometry and Fraction of Exhaled Nitric Oxide measurement
  • Peak Nasal Inspiratory Flow measurement

Measurements 24 hours after training:

  • Collection of nasal fluid
  • Assessment of upper airway symptoms (Visual Analogue Score)
  • Spirometry and Fraction of Exhaled Nitric Oxide measurement
  • Peak Nasal Inspiratory Flow measurement
  • Sputum induction
  • Venous puncture (1 tube of 10 ml)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Performing sports at national or international level (swimmers and indoor athletes)

Exclusion criteria

  • Performing sport at recreational level (not more than 4 hours/week for healthy individuals)

Treatment and study plan

Primary outcomes

  1. Measurement of airway inflammation

    Time frame: Baseline, immediately after and 24 hours after sport-specific training

    Airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), Fraction of exhaled Nitric Oxide measurement and sputum induction.

Secondary outcomes

  1. Measurement of exercise induced bronchoconstriction

    Time frame: baseline

    Exercise induced bronchoconstriction will be assessed by eucapnic voluntary hyperventilation test.

Other outcomes

  1. Detection of allergy

    Time frame: baseline

    -Allergy will be assessed by skin prick test (on skin) and immunocap test (in blood, 1 tube of 10 ml).

  2. Assessment of upper and lower airway symptoms

    Time frame: Baseline, immediately after and 24 hours after sport-specific training

    -Upper and lower airway symptoms will be assessed by questionnaires (SinoNasal Outcome Measure-22, Visual Analogue Score, Asthma Symptom Score and Juniper Score)

  3. Measurement of lung function and nasal patency

    Time frame: at baseline, immediately after and 24 hours sport-specific training

    -Lung function and nasal patency will be measured by spirometry and Peak Nasal Inspiratory Flow measurement.

Sponsors and collaborators

Lead sponsor

Universitaire Ziekenhuizen KU Leuven

Other

Registry information

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Sep 13, 2013
Registry last updated
Jul 16, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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