Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07299500

Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital

Toxoplasmosis in HIV-positive individuals is well-studied and has a codified management protocol, which is not the case for other immunodeficiencies, except for recent recommendations in the context of hematopoietic stem cell transplantation. A description of this population is necessary to estimate the number of patients affected and to define their specific management (diagnosis, treatment, prevention).

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Cerebral Toxoplasmosis Abscess Brain Abscess Brain Diseases Central Nervous System Diseases Central Nervous System Infections Central Nervous System Parasitic Infections Central Nervous System Protozoal Infections Coccidiosis Immune System Diseases Immunologic Deficiency Syndromes Infections Nervous System Diseases Parasitic Diseases Protozoan Infections Suppuration Toxoplasmosis Toxoplasmosis, Cerebral

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult (≥18 years)
  • Immunocompromised (i.e., solid organ transplant recipient, hematological malignancy, cancer patient, patient treated with immunosuppressive therapy or therapy affecting the immune system by any mechanism, hematopoietic stem cell transplant recipient, patient with an autoimmune disease or immunodeficiency, whether primary or secondary).
  • At least one positive toxoplasmosis PCR test (regardless of tissue)

Exclusion criteria

  • Subject who has expressed opposition to the reuse of their data for scientific research.
  • HIV positive
  • Congenital toxoplasmosis
  • Isolated ocular toxoplasmosis in immunocompetent individuals

Treatment and study plan

Primary outcomes

  1. Overall patient survival rates

    Time frame: Up to 1 year

Study contacts

Contact information is provided by the study sponsor or research team.

Mathilde HERBER, MD

CONTACT

[email protected]

33 3.69.55.13.99

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Retrospective Descriptive Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital From 2010 to 2023

Acronym: TOXO

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 23, 2025
Registry last updated
Dec 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.