Study for Using Radiosurgery on Limited Metastases of Breast Cancer

Before treatment begins, you will have a physical exam and blood tests. Physical evaluations and blood tests will be done each week while you are receiving treatment, and at follow-up visits. You will be seen for follow-up evaluations 4 weeks after treatment is completed, and every three months thereafter. You will be asked to fill out a Quality of Life questionnaire, which should take 5-10 minutes to complete. This will be done prior to treatment and at your follow-up visits. You will receive high dose radiation therapy directed at the site of metastasis. This treatment will be given once a day, 5 times a week (Monday through Friday) for one to four weeks depending on the location and size of the disease to be treated.

Inclusion criteria

• Age: no limit
• Karnofsky performance status (KPS) ≥ 70
• No more than 5 metastatic sites involving one or more different organs (liver, lung or bone).
• The size of the lesion must be such that it can be safely treated to sterilizing radiation doses according to the rules in the protocol.
• Previously treated lesions are not eligible unless the prescribed dose can be safely delivered.
• Concurrent therapy is allowed and recommended. The chemotherapy protocol type and schedule are at the discretion of the medical oncologist.
• Informed consent must be obtained.
• Pregnancy test must be negative for women of child bearing potential

Exclusion criteria

• Inability of patient to be followed longitudinally as specified by protocol.
• Technical inability to achieve required dose based on safe dose constraints required for radiosurgery.
• Women who are pregnant or nursing.
• Failure to meet requirements in Inclusion Criteria
• Contraindications to radiation.