Study for the Liquid Chromatography-mass Spectrometry (LC-MS/MS) Assessment of Oxidative DNA Damage in Relation to Antioxidant Usage

In this pilot study, the overall purpose is to establish the molecular basis for the hypothesis that oxidative stress is a risk factor for cancer. This will be achieved by establishing base line levels of oxidative DNA damage in a population of healthy individuals before and after taking antioxidant and mineral supplements for 8 weeks.

Inclusion criteria

• Health male or female non-melanoma patients or volunteers
• 18 years or older with a life expectancy greater than 6 months
• Willing to provide pre and post blood samples to measure five DNA modifications in white blood cells
• Willing to participate in a one tablet a day eight week supplement program and to record the ingestion of the supplement on a participant calendar
• Must have never smoked or has not smoked for at least 6 months
• Informed of the investigational nature of the study, is able to provide informed consent and has signed thee informed consent form

Exclusion criteria

• Patients/healthy volunteers not meeting all of the above selection criteria.
• Patients/healthy volunteers who have a history of kidney stones within the last 5 years.
• Any participant with life threatening conditions including but not limited to cardiac failure, congestive heart failure, unstable coronary artery disease, uncontrolled hypertension, poorly controlled diabetes mellitus, kidney and liver disease,severe metabolic disorders and advanced cancer
• Patients not willing to comply with protocol requirements