Study Evaluating the Effect of UCB8600 on Mast Cell Activation in the Human Gut

Inclusion criteria

group 1 (resection tissue from surgery patients = healthy volunteers):

• Voluntary written informed consent of the participant has been obtained prior to any screening procedures
• At least 18 years of age at the time of signing the Informed Consent Form (ICF)
• Undergoing surgery for colorectal cancer
• No preoperative radiotherapy or chemotherapy

Exclusion criteria

group 1 (resection tissue from surgery patients = healthy volunteers):

• Using antihistamines such as ebastine, cetirizine, desloratadine, … (non-exhautive list) at the moment of surgery
• Inflammatory bowel disease (IBD) or diverticulitis
• Diabetes or BMI ≥ 30 kg/m²
• Subject is legally incapacitated

Inclusion criteria

group 2 (rectal biopsies from IBS patients):

• Voluntary written informed consent of the subject has been obtained prior to any screening procedures
• At least 18 years of age and maximum age of 65 years of age at the time of signing the Informed Consent Form (ICF)
• Diagnosed with IBS

Exclusion criteria

group 2 (rectal biopsies from IBS patients):

• Subject has internal/external hemorrhoids at the moment of biopsy sampling.
• Using bloodthinners such as Acenocoumarol, Aspirine (acetylsalicylzuur), Apixaban (Eliquis), Clopidogrel (Plavix), Dabigatran (Pradaxa), Edoxaban (Lixiana), Rivaroxaban (Xarelto), warfarine (Marevan®) and Enoxaparine (Clexane), … (non-exhausative list).
• Using antihistamines such as ebastine, cetirizine, desloratadine, … (non-exhausative list) at the moment of biopsy sampling. These should be stopped 2 weeks prior to the biopsy sampling.
• Subject is legally incapacitated