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Completed

NCT Number: NCT00705458

Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain

The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.

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Key information

Conditions

Coronary Artery Disease Acute Coronary Syndrome Angina Pectoris Angina, Unstable Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Chest Pain Coronary Disease Heart Diseases Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Unstable Angina Vascular Diseases

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Moses Division, Montefiore Medical Center

The Bronx, New York, 10467, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient admitted for chest pain or pressure
  • patient at intermediate short term risk of MI or death (AHA/ACC guidelines)

Exclusion criteria

  • prior diagnosis of coronary artery disease
  • evidence of ongoing myocardial infarction (and other high risk criteria per AHA/ACC guidelines)
  • contraindications to EKG-gated CT scanning with iodinated intravenous contrast under beta-blockade
  • pregnancy
  • presence of an implanted pacemaker or defibrillator
  • stress myocardial perfusion imaging, coronary CTA or coronary catheterization within the last 6 months

Treatment and study plan

coronary computed tomography angiography

Procedure

64-detector, retrospectively EKG-gated, computed tomography angiography of the coronary arteries during heart rate control (intravenous metoprolol, when necessary)

Other names: CCTA, Coronary CT, Coronary CTA, Coronary Artery CT, Coronary Artery CTA, Coronary CT Angiography, CTA of the Coronary Arteries

Stress Nuclear Myocardial Perfusion Imaging

Procedure

Usually dual-isotope perfusion imaging at rest (201-Thallium) and at stress (99m-Technetium-MIBI). Some patients will have a 2-day MIBI protocol. Gated SPECT and attenuation-correction images will be obtained. Treadmill stress will be performed. If a patient is unable to exercise, adenosine or dobutamine will be given.

Other names: stress test, nuclear stress test, dual-isotope stress test, sestamibi, thallium, myocardial perfusion imaging, nuclear perfusion imaging, gated SPECT, nuclear cardiology

Primary outcomes

  1. Coronary catheterization that does not lead to re-vascularization

    Time frame: 1 year

Secondary outcomes

  1. Length of Hospital Stay (time to discharge)

    Time frame: usually from hours to a few days (average about one day)

  2. Non-fatal myocardial infarction

    Time frame: 1 year

  3. Death (all cause)

    Time frame: 1 year

  4. Post-test renal dysfunction

    Time frame: usually within a few days

Sponsors and collaborators

Lead sponsor

Montefiore Medical Center

Other

Collaborators

  • Albert Einstein College of Medicine
  • American Heart Association

Registry information

Official study title

A Randomized Trial Comparing Multi-Detector Coronary CT Angiography and Stress Myocardial Perfusion Imaging as the Initial Test for the Diagnosis of Coronary Artery Disease in Intermediate Risk Patients Admitted for Chest Pain

Acronym: PROSPECT

Important dates

Study start
2008
Primary completion
2013
Study completion
2013
First posted
Jun 26, 2008
Registry last updated
Aug 25, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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