Study Comparing Appearance and Function of Three Different Dental Implant Designs When Placed in Front Region of Upper Jaw

Inclusion criteria

• Provision of informed consent
• At least 18 years
• In need of one or more single implants replacing missing or non-restorable teeth in the maxilla within region 14 to 24

The following should be considered at inclusion but can not be fulfilled until at Visit 2:

• Edentulous for at least 5 months at study site
• A buccal-lingual bone width at study site of at least 5.5 mm
• A mesial-distal bone level distance between adjacent teeth at study site of at least 5.5 mm
• A keratinized mid-buccal mucosal height of at least 2 mm at study site
• Teeth adjacent (mesial and distal) to study site must consist of two stable teeth on natural roots without signs of periodontal bone loss (>1 mm) and/or significant soft tissue loss
• Teeth adjacent (mesial and distal) to study site must demonstrate a stable occlusal guidance that will allow non-functional disclusion in all eccentric positions
• An opposing dentition with teeth, implants or prosthesis

Exclusion criteria

• Insufficient interocclusal distance for implant placement and restoration at study site
• Tooth adjacent (mesial and/or distal) to study site is ankylosed
• More than 2 mm vertical bone loss at study site as measured from the mid-buccal crest of bone on the adjacent teeth
• Site development (bone tissue) performed at less than 5 months before Visit 2 at study site
• Untreated rampant caries and/or uncontrolled periodontal disease
• Class II division 2 malocclusion (Edward Hartley Angle)
• Use of tobacco within last 6 months
• Uncontrolled diabetes (subjects history does not reveal the absence of control of insulin-dependent/non-insulin dependent Diabetes Mellitus)
• Current alcohol or drug abuse
• Systemic or local disease or condition that would compromise post-operative healing and/or osseointegration
• Use of any substance that will influence bone metabolism
• Need for systemic corticosteroids or any other medication that would influence post-operative healing and/or osseointegration
• History of radiation in the head and neck region
• Known pregnancy, pregnancy tests will be performed as per local requirements.
• Unable or unwilling to return for follow-up visits for a period of 5 years
• Unlikely to be able to comply with study procedures according to Investigators judgement
• Involvement in the planning and conduct of the study (applies to both Astra Tech staff or staff at the study center)
• Previous enrollment or randomization of treatment in the present study.