Study by Electroencephalography of the Link Between the Lack of Self-compassion and the Disorder of Empathy in Schizophrenia

This study includes patients (n=30) and healthy volunteers (n=30).

At inclusion visit, participants have:

• a psychiatric evaluation;
• self evaluation of: empathy, self-compassion, émotionnel processing, anxiety, insight, perceptual aberration and quality of life;
• training to practise of self-compassion and empathy (for patients only).

During the phase of experimentation, the participants have electroencephalogram exams during a rest phase, a self-compasion task and an empathy task.

Inclusion criteria

for the patient group :

• patients with a schizophrenic or schizoaffective disorder according to the DSM-5 criteria (axis 1), with no other pathology of axis 1, except addiction to tobacco
• patients stabilized for at least 3 months for their psychotic disorders
• patients with disease duration > 2 years but < 20 years
• patients whose treatment has not been changed or modified in the previous month
• patients on stable treatments who should not change treatment during the study (good compliance, good tolerance)
• patients who do not benefit from a neuromodulation protocol for their symptoms (rTMS, TDCS)
• patients who do not benefit from a cognitive remediation program
• patients between the ages of 18 and 60
• men and women
• patients with normal or corrected vision
• patients without mental impairment
• patients without neurological impairment (epilepsy, encephalopathy, head trauma)
• patients with a sufficient command of French
• patients free or under protective measures
• patients benefiting from coverage by a social security scheme or benefiting from it through a third party
• Having given their consent to participate in the study after having received written, clear and fair information (and after obtaining the consent of the tutor/curator if applicable)

Exclusion criteria

for the patient group :

• patients with an axis 1 pathology other than a schizophrenic or schizoaffective disorder (in particular, psychic trauma revealed by MINI and symptoms of PTSD (current as lifetime))
• patients with an addiction to alcohol or other toxic substances, except tobacco
• patients with suicidal intentionality
• patients not stabilized for their psychotic disorders and with regard to their antipsychotic treatments
• patients receiving antiepileptic treatment with mood-regulating, antidepressant and anxiolytic properties
• patients receiving benzodiazepine treatment that they could not stop 72 hours before the EEG
• patients with disease duration < 2 years or > 20 years
• patients with an IQ < 70
• patients benefiting from a neuromodulation protocol (rTMS, TDCS)
• patients benefiting from a cognitive remediation program
• patients with a PANSS > or = 5 for items G8 (hostility) and P7 (non-cooperation)
• patients aged < 18 years or > 60 years
• patients with mental impairment
• patients with neurological impairment (epilepsy, encephalopathy, head trauma)
• patients with documented neurological pathology or medical condition that may explain the psychotic manifestations
• patients who do not speak French well enough
• subjects residing within a radius greater than 50 km from the hospital
• patients hospitalized under duress
• patients without social security

Inclusion criteria

for the control group:

• healthy volunteers without schizophrenic or schizoaffective disorder and without other psychiatric pathologies as defined by the DSM 5 (axis 1) (in particular, absence of psychic trauma revealed by the MINI and of PTSD (current as whole life))
• subjects aged 18 to 60
• men and women
• subjects with normal or corrected vision
• subjects without mental impairment
• subjects without neurological impairment (epilepsy, encephalopathy, head trauma)
• free subjects, without guardianship or curatorship or subordination
• subjects benefiting from coverage by a social security scheme or benefiting from it through a third party
• Having given their consent to participate in the study after having received written, clear and honest information.

Exclusion criteria

for the control group:

• subjects with a psychiatric pathology as defined in the DSM-5 (axis 1) (in particular, psychic trauma revealed by the MINI and symptoms of PTSD (current as lifetime))
• subjects aged < 18 years or > 60 years
• subjects with a mental deficiency
• subjects with neurological pathology
• subjects with a medical condition preventing them from participating in the study
• subjects residing within a radius greater than 50 km from the hospital
• subjects under guardianship or curatorship
• subjects not benefiting from a Social Security scheme or not benefiting from it through a third party